Negative symptoms and speech pauses in youths at clinical high risk for psychosis

doi:10.1038/s41537-020-00132-1

. 2021 Jan 22;7(1):3.

doi: 10.1038/s41537-020-00132-1.

Negative symptoms and speech pauses in youths at clinical high risk for psychosis

Emma R Stanislawski¹, Zarina R Bilgrami¹, Cansu Sarac¹, Sahil Garg¹, Stephen Heisig¹, Guillermo A Cecchi², Carla Agurto², Cheryl M Corcoran^{3

4}

Affiliations

¹ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
³ Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cheryl.corcoran@mssm.edu.
⁴ James J. Peters VA Medical Center, Bronx, NY, USA. Cheryl.corcoran@mssm.edu.

PMID: 33483485
PMCID: PMC7822906
DOI: 10.1038/s41537-020-00132-1

Negative symptoms and speech pauses in youths at clinical high risk for psychosis

Emma R Stanislawski et al. NPJ Schizophr. 2021.

. 2021 Jan 22;7(1):3.

doi: 10.1038/s41537-020-00132-1.

Authors

Emma R Stanislawski¹, Zarina R Bilgrami¹, Cansu Sarac¹, Sahil Garg¹, Stephen Heisig¹, Guillermo A Cecchi², Carla Agurto², Cheryl M Corcoran^{3

4}

Affiliations

¹ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
³ Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cheryl.corcoran@mssm.edu.
⁴ James J. Peters VA Medical Center, Bronx, NY, USA. Cheryl.corcoran@mssm.edu.

PMID: 33483485
PMCID: PMC7822906
DOI: 10.1038/s41537-020-00132-1

Abstract

Aberrant pauses are characteristic of schizophrenia and are robustly associated with its negative symptoms. Here, we found that pause behavior was associated with negative symptoms in individuals at clinical high risk (CHR) for psychosis, and with measures of syntactic complexity-phrase length and usage of determiners that introduce clauses-that we previously showed in this same CHR cohort to help comprise a classifier that predicted psychosis. These findings suggest a common impairment in discourse planning and verbal self-monitoring that affects both speech and language, and which is detected in clinical ratings of negative symptoms.

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1. Associations of negative symptom severity and pause behavior.**
Panel 1a shows the association of negative symptom severity with mean pause length in seconds. Panel 1b shows the association of negative symptoms severity with percentage of pauses.

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References

1. Lundholm Fors, K. Production and Perception of Pauses in Speech (University of Gothenburg, 2015).
1. Roberts, F. & Francis, A. L. Identifying a temporal threshold of tolerance for silent gaps after requests. J. Acoust. Soc. Am. 10.1121/1.4802900 (2013). - PubMed
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1. Sichlinger, L., Cibelli, E., Goldrick, M. & Mittal, V. A. Clinical correlates of aberrant conversational turn-taking in youth at clinical high-risk for psychosis. Schizophr. Res.10.1016/j.schres.2018.08.009 (2019). - PMC - PubMed
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[1] Lundholm Fors, K. Production and Perception of Pauses in Speech (University of Gothenburg, 2015).

[2] Lundholm Fors, K. Production and Perception of Pauses in Speech (University of Gothenburg, 2015).

[3] Roberts, F. & Francis, A. L. Identifying a temporal threshold of tolerance for silent gaps after requests. J. Acoust. Soc. Am. 10.1121/1.4802900 (2013). - PubMed

[4] Roberts, F. & Francis, A. L. Identifying a temporal threshold of tolerance for silent gaps after requests. J. Acoust. Soc. Am. 10.1121/1.4802900 (2013). - PubMed

[5] Cohen, A. S., Mitchell, K. R., Docherty, N. M. & Horan, W. P. Vocal expression in schizophrenia: Less than meets the ear. J. Abnorm. Psychol. 10.1037/abn0000136 (2016). - PMC - PubMed

[6] Cohen, A. S., Mitchell, K. R., Docherty, N. M. & Horan, W. P. Vocal expression in schizophrenia: Less than meets the ear. J. Abnorm. Psychol. 10.1037/abn0000136 (2016). - PMC - PubMed

[7] Sichlinger, L., Cibelli, E., Goldrick, M. & Mittal, V. A. Clinical correlates of aberrant conversational turn-taking in youth at clinical high-risk for psychosis. Schizophr. Res.10.1016/j.schres.2018.08.009 (2019). - PMC - PubMed

[8] Sichlinger, L., Cibelli, E., Goldrick, M. & Mittal, V. A. Clinical correlates of aberrant conversational turn-taking in youth at clinical high-risk for psychosis. Schizophr. Res.10.1016/j.schres.2018.08.009 (2019). - PMC - PubMed

[9] Bedi G, et al. Automated analysis of free speech predicts psychosis onset in high-risk youths. NPJ Schizophr. 2015;1:115030. doi: 10.1038/npjschiz.2015.30. - DOI - PMC - PubMed

[10] Bedi G, et al. Automated analysis of free speech predicts psychosis onset in high-risk youths. NPJ Schizophr. 2015;1:115030. doi: 10.1038/npjschiz.2015.30. - DOI - PMC - PubMed

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Negative symptoms and speech pauses in youths at clinical high risk for psychosis

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Negative symptoms and speech pauses in youths at clinical high risk for psychosis

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