Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb;69(1):8-17.
doi: 10.1007/s12026-021-09177-5. Epub 2021 Jan 23.

Effects of functionally diverse calpain system on immune cells

Yueqi Chen  1   2 , Zhaoliang Su  1   2 , Fang Liu  3
Affiliations
Review

Effects of functionally diverse calpain system on immune cells

Yueqi Chen et al. Immunol Res. 2021 Feb.

Abstract

Calpains are a family of nonlysosomal cysteine proteases, which play important roles in numerous physiological and pathological processes. Locations of them dictates the functions so that they are classified as ubiquitously expressed calpains and tissue-specific calpains. Recent studies are mainly focused on conventional calpains (calpain-1,2) in development and diseases, and increasing people pay attention to other subtypes of calpains but may not been summarized appropriately. Growing evidence suggests that calpains are also involved in immune regulation. However, seldom articles review the regulation of calpains on immune cells. The aim of this article is to review the research progress of each calpain isozyme and the effect of calpains on immune cells, especially the promotion effect of calpains on the immune response of macrophage, neutrophils, dendritic cells, mast cells, natural killed cells, and lymphocytes. These effects would hold great promise for the clinical application of calpains as a practicable therapeutic option in the treatment of immune related diseases.

Keywords: Calpain inhibition; Calpain system; Immune cells; Immune regulation.

PubMed Disclaimer

References

    1. Araujo H, Julio A, Cardoso M. Translating genetic, biochemical and structural information to the calpain view of development. Mech Dev. 2018;154:240–50. - PubMed
    1. Tamtaji OR, Mirhosseini N, Reiter RJ, Azami A, Asemi Z. Melatonin, a calpain inhibitor in the central nervous system: current status and future perspectives. J Cell Physiol. 2019;234(2):1001–7. - PubMed
    1. Mahaman YAR, Huang F, Kessete Afewerky H, Maibouge TMS, Ghose B, Wang X. Involvement of calpain in the neuropathogenesis of Alzheimer's disease. Med Res Rev. 2019;39(2):608–30. - PubMed
    1. Nevzorova TA, Mordakhanova ER, Daminova AG, Ponomareva AA, Andrianova IA, Le Minh G, et al. Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death. Cell Death Discov. 2019;5:106. - PubMed - PMC
    1. Miyazaki T, Akasu R, Miyazaki A. Calpain proteolytic systems counteract endothelial cell adaptation to inflammatory environments. Inflamm Regen. 2020;40:5. - PubMed - PMC

Publication types

LinkOut - more resources