Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;41(4):1479-1485.
doi: 10.1007/s10792-021-01708-1. Epub 2021 Jan 23.

Topical cyclosporine a (0.05%) treatment in dry eye patients: a comparison study of Sjogren's syndrome versus non-Sjogren's syndrome

Mehmet Ozgur Cubuk  1 , Ahmet Yucel Ucgul  2 , Armagan Ozgur  3 , Kemal Ozulken  4 , Erdem Yuksel  5   6
Affiliations

Topical cyclosporine a (0.05%) treatment in dry eye patients: a comparison study of Sjogren's syndrome versus non-Sjogren's syndrome

Mehmet Ozgur Cubuk et al. Int Ophthalmol. 2021 Apr.

Abstract

Purpose: To evaluate the clinical effect of topical cyclosporine A (CsA) (0.05%) on dry eye patients with Sjogren's syndrome (SS) and non-Sjogren's syndrome (NSS).

Method: This retrospective comparative study includes the dry eye (DE) patients who were treated with topical CsA. DE patients were divided into two groups as follows: DE with Sjogren's syndrome (DE-SS) and DE with Non-Sjogren's syndrome (DE-NSS). Dry eye parameters were recorded at baseline and each visit.

Results: Schirmer's test 1 scores were 2.7 ± 0.5 mm at baseline and 3.5 ± 0.7 mm at 12th month in DE-SS, 2.9 ± 0.7 mm at baseline and 9.5 ± 0.7 mm in DE-NSS groups at 12th month. Mean ST score was higher in DE-NSS group than DE-SS group at sixth and 12th months of the treatment (both p = 0.001). Tear break-up time score showed a significant improvement in DE-NSS group, and it was lower in DE-NSS group than DE-SS group group at sixth and 12th months of the treatment (p = 0.044 and 0.027, respectively). Mean OSDI score was lower in DE-NSS group than DE-SS group at sixth and 12th months of the treatment (p = 0.030 and 0.032, respectively).

Conclusion: Topical CsA seems to be more effective in the treatment of the DE-NSS.

Keywords: Cyclosporine; Dry eye; Non-sjogren’s syndrome; Sjogren’s syndrome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. (2007) The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 5(2):75–92. https://doi.org/10.1016/s1542-0124(12)70081-2
    1. Bron AJ, de Paiva CS, Chauhan SK et al (2017) TFOS DEWS II pathophysiology report. Ocul Surf 15(3):438–510 - DOI
    1. Hikichi T, Yoshida A, Tsubota K (1993) Lymphocytic infiltration of the conjunctiva and the salivary gland in Sjogren’s syndrome. Arch Ophthalmol 111(1):21–22 - PubMed
    1. Lee SY, Han SJ, Nam SM et al (2013) Analysis of tear cytokines and clinical correlations in Sjogren syndrome dry eye patients and non-Sjogren syndrome dry eye patients. Am J Ophthalmol 156(2):247–253 - DOI
    1. Liu R, Gao C, Chen H, Li Y, Jin Y, Qi H (2017) Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease. PLoS ONE 12(4):e0173301 - DOI

LinkOut - more resources