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Review
. 2021 Jan;44(1):63-83.
doi: 10.1007/s12272-021-01306-w. Epub 2021 Jan 23.

Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes

Yeo-Jung Kwon  1 , Sangyun Shin  1 , Young-Jin Chun  2
Affiliations
Review

Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes

Yeo-Jung Kwon et al. Arch Pharm Res. 2021 Jan.

Abstract

Human cytochrome P450 enzymes (CYPs) play a critical role in various biological processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and CYP1B1, are induced by aryl hydrocarbon receptors (AhRs). The binding of ligands such as polycyclic aromatic hydrocarbons activates the AhRs, which are involved in the metabolism (including oxidation) of various endogenous or exogenous substrates. The ligands that induce CYP1 expression are reported to be carcinogenic xenobiotics. Hence, CYP1 enzymes are correlated with the pathogenesis of cancers. Various endogenous substrates are involved in the metabolism of steroid hormones, eicosanoids, and other biological molecules that mediate the pathogenesis of several human diseases. Additionally, CYP1s metabolize and activate/inactivate therapeutic drugs, especially, anti-cancer agents. As the metabolism of drugs determines their therapeutic efficacy, CYP1s can determine the susceptibility of patients to some drugs. Thus, understanding the role of CYP1s in diseases and establishing novel and efficient therapeutic strategies based on CYP1s have piqued the interest of the scientific community.

Keywords: Cancer; Cytochrome P450 (CYP) 1 enzymes; Drug metabolism; Metabolic diseases; Polymorphism.

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References

    1. Achary MS, Reddy AB, Chakrabarti S, Panicker SG, Mandal AK, Ahmed N, Balasubramanian D, Hasnain SE, Nagarajaram HA (2006) Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans. Biophys J 91:4329–4339. https://doi.org/10.1529/biophysj.106.085498 - DOI - PubMed - PMC
    1. Afzal R, Firasat S, Kaul H, Ahmed B, Siddiqui SN, Zafar SN, Shahzadi M, Afshan K (2019) Mutational analysis of the CYP1B1 gene in Pakistani primary congenital glaucoma patients: identification of four known and a novel causative variant at the 3’ splice acceptor site of intron 2. Congenit Anom (Kyoto) 59:152–161. https://doi.org/10.1111/cga.12312 - DOI
    1. Aldrich MC, Selvin S, Hansen HM, Barcellos LF, Wrensch MR, Sison JD, Kelsey KT, Buffler PA, Quesenberry CP Jr., Seldin MF, Wiencke JK (2009) CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification. Cancer Res 69:2340–2348. https://doi.org/10.1158/0008-5472.CAN-08-2576 - DOI - PubMed - PMC
    1. Alsubait A, Aldossary W, Rashid M, Algamdi A, Alrfaei BM (2020) CYP1B1 gene: implications in glaucoma and cancer. J Cancer 11:4652–4661. https://doi.org/10.7150/jca.42669 - DOI - PubMed - PMC
    1. Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM, kConFab Investigators, Vink JM, Rawal R, Mangino M, Teumer A, Keers JC, Verwoert G, Baumeister S, Biffar R, Petersmann A, Dahmen N, Doering A, Isaacs A, Broer L, Wray NR, Montgomery GW, Levy D, Psaty BM, Gudnason V, Chakravarti A, Sulem P, Gudbjartsson DF, Kiemeney LA, Thorsteinsdottir U, Stefansson K, van Rooij FJA, Aulchenko YS, Hottenga JJ, Rivadeneira FR, Hofman A, Uitterlinden AG, Hammond CJ, Shin SY, Ikram A, Witteman JCM, Janssens ACJW, Snieder H, Tiemeier H, Wolfenbuttel BHR, Oostra BA, Heath AC, Wichmann E, Spector TD, Grabe HJ, Boomsma DI, Martin NG, van Duijn CM (2012) Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry 17:1116–1129. https://doi.org/10.1038/mp.2011.101 - DOI - PubMed

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