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. 2021 Apr;41(5):584-590.
doi: 10.1002/pd.5910. Epub 2021 Feb 13.

Missed connections: recombination and human aneuploidy

Terry J Hassold  1 , Patricia A Hunt  1
Affiliations

Missed connections: recombination and human aneuploidy

Terry J Hassold et al. Prenat Diagn. 2021 Apr.

Abstract

The physical exchange of DNA between homologs, crossing-over, is essential to orchestrate the unique, reductional first meiotic division (MI). In females, the events of meiotic recombination that serve to tether homologs and facilitate their disjunction at MI occur during fetal development, preceding the MI division by several decades in our species. Data from studies in humans and mice demonstrate that placement of recombination sites during fetal development influences the likelihood of an MI nondisjunction event that results in the production of an aneuploid egg. Here we briefly summarize what we know about the relationship between aneuploidy and meiotic recombination and important considerations for the future of human assisted reproduction.

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References

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