Recent, Mid, and Late Adulthood Antibiotic Use Are Associated With Subsequent Risk of Diverticulitis

doi:10.1053/j.gastro.2021.01.200

. 2021 May;160(6):2172-2174.e3.

doi: 10.1053/j.gastro.2021.01.200. Epub 2021 Jan 20.

Recent, Mid, and Late Adulthood Antibiotic Use Are Associated With Subsequent Risk of Diverticulitis

Long H Nguyen¹, Chuan-Guo Guo², Wenjie Ma¹, Edward L Giovannucci³, Lisa L Strate⁴, Andrew T Chan⁵

Affiliations

¹ Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
² Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
⁴ Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington.
⁵ Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Electronic address: achan@partners.org.

PMID: 33484687
PMCID: PMC8459316
DOI: 10.1053/j.gastro.2021.01.200

Recent, Mid, and Late Adulthood Antibiotic Use Are Associated With Subsequent Risk of Diverticulitis

Long H Nguyen et al. Gastroenterology. 2021 May.

. 2021 May;160(6):2172-2174.e3.

doi: 10.1053/j.gastro.2021.01.200. Epub 2021 Jan 20.

Authors

Long H Nguyen¹, Chuan-Guo Guo², Wenjie Ma¹, Edward L Giovannucci³, Lisa L Strate⁴, Andrew T Chan⁵

Affiliations

¹ Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
² Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
³ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
⁴ Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington.
⁵ Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Electronic address: achan@partners.org.

PMID: 33484687
PMCID: PMC8459316
DOI: 10.1053/j.gastro.2021.01.200

No abstract available

PubMed Disclaimer

Cited by

Risk Prediction in Diverticulitis.
Velez-Padilla J, Pastrana Del Valle J, Cavallaro P. Velez-Padilla J, et al. Clin Colon Rectal Surg. 2024 Sep 30;38(4):263-268. doi: 10.1055/s-0044-1791497. eCollection 2025 Jul. Clin Colon Rectal Surg. 2024. PMID: 40501523 Review.
Right-Sided Infectious Endocarditis in the Patient With Williams Syndrome: Importance of Recognizing Disease-Specific Pathophysiology in Adults.
Nakano S, Saiki H, Saito K, Sato A, Takizawa Y, Kuwata S, Oyama K. Nakano S, et al. Cureus. 2025 Jun 12;17(6):e85871. doi: 10.7759/cureus.85871. eCollection 2025 Jun. Cureus. 2025. PMID: 40520836 Free PMC article.

References

1. Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology 2009;136:376–86. - PubMed
1. Young-Fadok TM. Diverticulitis. N Engl J Med 2018;379:1635–1642. - PubMed
1. Stollman N, Smalley W, Hirano I. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology 2015;149:1944–9. - PubMed
1. Dethlefsen L, Huse S, Sogin ML, et al.The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008;6:e280. - PMC - PubMed
1. Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A 2011;108 Suppl 1:4554–61. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology 2009;136:376–86. - PubMed

[2] Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology 2009;136:376–86. - PubMed

[3] Young-Fadok TM. Diverticulitis. N Engl J Med 2018;379:1635–1642. - PubMed

[4] Young-Fadok TM. Diverticulitis. N Engl J Med 2018;379:1635–1642. - PubMed

[5] Stollman N, Smalley W, Hirano I. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology 2015;149:1944–9. - PubMed

[6] Stollman N, Smalley W, Hirano I. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology 2015;149:1944–9. - PubMed

[7] Dethlefsen L, Huse S, Sogin ML, et al.The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008;6:e280. - PMC - PubMed

[8] Dethlefsen L, Huse S, Sogin ML, et al.The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008;6:e280. - PMC - PubMed

[9] Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A 2011;108 Suppl 1:4554–61. - PMC - PubMed

[10] Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A 2011;108 Suppl 1:4554–61. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Recent, Mid, and Late Adulthood Antibiotic Use Are Associated With Subsequent Risk of Diverticulitis

Affiliations

Recent, Mid, and Late Adulthood Antibiotic Use Are Associated With Subsequent Risk of Diverticulitis

Authors

Affiliations

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical