Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2021 May:232:287-289.e4.
doi: 10.1016/j.jpeds.2021.01.027. Epub 2021 Jan 21.

Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Serena Villaverde  1 , Sara Domínguez-Rodríguez  2 , Gema Sabrido  3 , Conchita Pérez-Jorge  4 , Marta Plata  5 , María Pilar Romero  6 , Carlos Daniel Grasa  7 , Ana Belén Jiménez  8 , Elena Heras  8 , Antonio Broncano  9 , María Del Mar Núñez  10 , Marta Illán  11 , Paloma Merino  12 , Beatriz Soto  13 , David Molina-Arana  14 , Amanda Bermejo  15 , Pablo Mendoza  16 , Manuel Gijón  17 , Begoña Pérez-Moneo  18 , Cinta Moraleda  19 , Alfredo Tagarro  20 ; Epidemiological Study of COVID-19 in Children of the Spanish Society of Pediatric (EPICO-AEP) Working Group
Collaborators, Affiliations
Comparative Study

Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Serena Villaverde et al. J Pediatr. 2021 May.

Abstract

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.

Keywords: COVID-19; PCR; SARS-CoV-2; antigen test.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overall sensitivity, specificity, and predictive values for rapid antigenic test Panbio using RT-PCR as the gold-standard reference.
Figure 2
Figure 2
Representation of sensitivity, specificity, and predictive values for rapid antigenic test Panbio using RT-PCR as the gold-standard reference.
See this image and copyright information in PMC

Comment in

  • Diagnostic performance of antigen testing for severe acute respiratory syndrome coronavirus 2.
    Marchán-López Á, Ayuso García B. Marchán-López Á, et al. J Pediatr. 2021 Jun;233:283. doi: 10.1016/j.jpeds.2021.02.052. Epub 2021 Feb 22. J Pediatr. 2021. PMID: 33631167 Free PMC article. No abstract available.
  • Reply.
    Villaverde S, Merino-Amador P, Mendoza P, Molina-Arana D, Romero MP, Moraleda C, Tagarro A. Villaverde S, et al. J Pediatr. 2021 Jun;233:283-284. doi: 10.1016/j.jpeds.2021.02.051. Epub 2021 Feb 22. J Pediatr. 2021. PMID: 33631168 Free PMC article. No abstract available.

References

    1. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Overview of Testing for SARS-CoV-2 (COVID-19). Updated October 21, 2020. [Internet]. https://www.cdc.gov/coronavirus/2019-ncov/hcp/testing-overview.html
    1. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Information for Laboratories about Coronavirus (COVID-19). Updated October 16, 2020. [Internet]. https://www.cdc.gov/coronavirus/2019-ncov/lab/index.html
    1. Linares M., Pérez-Tanoira R., Carreo A., Romanyk J., Pérez-García F., Gómez-Herruz P., et al. Panbio antigen rapid test is reliable to diagnose SARS-CoV-2 infection in the first 7 days after the onset of symptoms. J Clin Virol. 2020;133:104659. - PMC - PubMed
    1. Albert E., Torres I., Bueno F., Huntley D., Moya E., Fernandez-Funtes M.A., et al. Field evaluation of a rapid antigen test (Panbio COVID-19 Ag Rapid Test Device) for the diagnosis of COVID-19 in primary healthcare centers. medRxiv. 2020 http://medrxiv.org/content/early/2020/10/20/2020.10.16.20213850.abstract [Internet]. Accessed December 1, 2020. pre-print(96):2020.10.16.20213850. - PMC - PubMed
    1. Subirana I., Sanz H., Vila J. Building Bivariate tables: the compareGroups package for R. J Stat Softw. 2014;57:11–16.