Allogenic hematopoietic stem cell transplantation in sickle cell disease

Abstract

Sickle cell disease (SCD) is one of the most common monogenic disorders worldwide and affects approximately 100,000 people in the United States alone. SCD can cause numerous complications, including anemia, pain, stroke, and organ failure, which can lead to death. Although there are a few disease-modifying treatments available to patients with SCD, the only current curative option is a hematopoietic stem cell transplant (HSCT). In this review, we will discuss the different approaches to allogeneic HSCT in the treatment of SCD and the outcomes of these approaches.

Keywords: Allogeneic transplantation; Alternative donor; Haploidentical transplantation; Hematopoietic stem cell transplantation; Matched sibling; Sickle cell disease.