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Observational Study
. 2022 Oct;20(10):2393-2395.e4.
doi: 10.1016/j.cgh.2021.01.023. Epub 2021 Jan 21.

Weight Loss and Weight Regain in Usual Clinical Practice: Results From the TARGET-NASH Observational Cohort

Miguel H Malespin  1 , Alfred Sidney Barritt 4th  2 , Stephanie E Watkins  3 , Cheryl Schoen  3 , Monica A Tincopa  4 , Karen D Corbin  5 , Andrea R Mospan  3 , Breda Munoz  3 , Huy N Trinh  6 , L Michael Weiss  7 , K Rajender Reddy  8 , Rohit Loomba  9 , Nyingi Kemmer  1 , Anna S Lok  10
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Free article
Observational Study

Weight Loss and Weight Regain in Usual Clinical Practice: Results From the TARGET-NASH Observational Cohort

Miguel H Malespin et al. Clin Gastroenterol Hepatol. 2022 Oct.
Free article

Abstract

First-line treatment for nonalcoholic fatty liver disease (NAFLD) focuses on weight loss through lifestyle modifications.1,2 Weight loss ≥5% results in reduction of steatosis and weight loss ≥10% has been associated with improvement in hepatic inflammation and fibrosis.3 The incidence and sustainability of weight loss among patients with NAFLD were estimated and associating factors identified.

Trial registration: ClinicalTrials.gov NCT02815891.

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