Homologous recombination repair deficiency (HRD): From biology to clinical exploitation

David Gonzalez¹, Albrecht Stenzinger^{2

3

4}

Affiliations

¹ Patrick G Johnston Centre for Cancer Research, Queens University Belfast, Belfast, UK.
² Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
³ German Cancer Consortium (DKTK), Heidelberg, Germany.
⁴ German Center for Lung Research (DZL), Heidelberg, Germany.

Editorial

David Gonzalez et al. Genes Chromosomes Cancer. 2021 May.

. 2021 May;60(5):299-302.

doi: 10.1002/gcc.22939. Epub 2021 Feb 10.

David Gonzalez¹, Albrecht Stenzinger^{2

3

4}

¹ Patrick G Johnston Centre for Cancer Research, Queens University Belfast, Belfast, UK.
² Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
³ German Cancer Consortium (DKTK), Heidelberg, Germany.
⁴ German Center for Lung Research (DZL), Heidelberg, Germany.

No abstract available

Keywords: PARP inhibitor; breast cancer; homologous recombination repair; ovarian cancer; pancreatic cancer; prostate cancer.

References

1. Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372(26):2509-2520. https://doi.org/10.1056/NEJMoa1500596.
1. Heeke AL, Pishvaian MJ, Lynce F, et al. Prevalence of homologous recombination-related gene mutations across multiple cancer types. JCO Precis Oncol. 2018;2:1-13. https://doi.org/10.1200/PO.17.00286.
1. Chang HHY, Pannunzio NR, Adachi N, Lieber MR. Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol. 2017;18(8):495-506. https://doi.org/10.1038/nrm.2017.48.
1. Lord CJ, Ashworth A. PARP inhibitors: synthetic lethality in the clinic. Science. 2017;355(6330):1152-1158. https://doi.org/10.1126/science.aam7344.
1. McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res. 2006;66(16):8109-8115. https://doi.org/10.1158/0008-5472.CAN-06-0140.