Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr;46(4):253-254.
doi: 10.1016/j.tibs.2021.01.001. Epub 2021 Jan 21.

Seeing Atoms by Single-Particle Cryo-EM

Xiao-Chen Bai  1
Affiliations
Comment

Seeing Atoms by Single-Particle Cryo-EM

Xiao-Chen Bai. Trends Biochem Sci. 2021 Apr.

Abstract

Nakane et al. and Yip et al., for the first time, demonstrate that, with recent technological advances, atomic-resolution structure determination can be achieved by single-particle cryo-electron microscopy (cryo-EM). This breakthrough opens the door for researchers to apply single-particle cryo-EM to obtain atomic structural information for a wide range of protein complexes.

Keywords: atomic resolution; single-particle cryo-EM; structural biology.

PubMed Disclaimer

Comment on

  • Atomic-resolution protein structure determination by cryo-EM.
    Yip KM, Fischer N, Paknia E, Chari A, Stark H. Yip KM, et al. Nature. 2020 Nov;587(7832):157-161. doi: 10.1038/s41586-020-2833-4. Epub 2020 Oct 21. Nature. 2020. PMID: 33087927
  • Single-particle cryo-EM at atomic resolution.
    Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PMGE, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchański T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SHW. Nakane T, et al. Nature. 2020 Nov;587(7832):152-156. doi: 10.1038/s41586-020-2829-0. Epub 2020 Oct 21. Nature. 2020. PMID: 33087931 Free PMC article.

MeSH terms

LinkOut - more resources