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Case Reports
. 2020 Nov-Dec;65(6):522-525.
doi: 10.4103/ijd.IJD_481_20.

Hand-Foot Skin Reaction with Sunitinib: A Rare Case Report with Review of Literature

Suchibrata Das  1 , Alok K Roy  1 , Srutee Barman  1 , Aritra Roy  1
Affiliations
Case Reports

Hand-Foot Skin Reaction with Sunitinib: A Rare Case Report with Review of Literature

Suchibrata Das et al. Indian J Dermatol. 2020 Nov-Dec.

Abstract

Newer multi-kinase inhibitors (MKI) like sunitinib have changed the therapy of patients of renal cell carcinoma, hepatocellular carcinoma, and gastrointestinal stromal tumor. The use of sunitinib also led to cutaneous toxicity, known as hand-foot skin reaction (HFSR). We report a case of hand-foot skin reaction (HFSR) in an Indian patient being treated with sunitinib. Respective literature on this disorder is also reviewed.

Keywords: Adverse cutaneous drug reactions; hand-foot skin reaction; kinase inhibitors; sunitinib.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
a,b- Yellow-colored callus-like hyperkeratotic plaques. c- Blisters are on side of 2nd toes and dorsum of one foot. d- Blister surrounded by erythema
Figure 2
Figure 2
a- Hyperkeratotic plaques. b - Erythema on finger tips. c- Ulcerated and crusted lesions on extensor of elbows. d- Angular cheilitis
Figure 3
Figure 3
a- Subsiding hyperkeratotic lesion and erythema. b- Subsiding crusted lesion. c- Subsiding hyperkeratotic lesion. d- Subsiding blister lesion, leaving minimal change. e- Crusted healed lesion at lower back
See this image and copyright information in PMC

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