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. 2020 Dec;23(12):1603-1609.
doi: 10.22038/ijbms.2020.48294.11089.

Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity

Erdem Toktay  1 , Jale Selli  2 , Muhammed Ali Gurbuz  3 , Tugba Bal Tastan  3 , Rustem Anıl Ugan  4 , Harun Un  5 , Zekai Halici  6
Affiliations

Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity

Erdem Toktay et al. Iran J Basic Med Sci. 2020 Dec.

Abstract

Objectives: This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.

Materials and methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically.

Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β3, integrin αvβ3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups. In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner.

Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein.

Keywords: Daidzein; Endometrial Receptivity; Genistein; Rat; Soy Isoflavonoids.

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Figures

Figure 1
Figure 1
Hematoxylin-eosin stainingand alcian blue staining findings in uterus tissue
Figure 2
Figure 2
Integrin ß3, Integrin avß3, LIF, HOXA10 and MUC1 Immunohistochemical Staining findings in uterine tissue
Figure 3
Figure 3
Serum levels of hormones estrogen and progesterone
See this image and copyright information in PMC

References

    1. Dilara Nilüfer DB. Soya ve Soya Ürünlerinin Fonksiyonel Gıda Bileşenleri. Dergipark. 2008;33:241–250.
    1. Dalu A, Haskell JF, Coward L, Lamartiniere CA. Genistein, a component of soy, inhibits the expression of the EGF and ErbB2/Neu receptors in the rat dorsolateral prostate. Prostate. 1998;37:36–43. - PubMed
    1. Wei HC, Bowen R, Cai QY, Barnes S, Wang Y. Anti-oxidant and antipromotional effects of the soybean isoflavone genistein. Proc Soc Exp Biol Med. 1995;208:124–130. - PubMed
    1. Kar PK, Tandon V, Saha NN. Anthelmintic efficacy of genistein, the active principle of Flemingia vestita (Fabaceae): Alterations in the free amino acid pool and ammonia levels in the fluke, Fasciolopsis buski. Parasitol Int. 2004;53:287–291. - PubMed
    1. Cooke PS, Selvaraj V, Yellayi S. Genistein, estrogen receptors, and the acquired immune response. J Nutr. 2006;136:704–708. - PubMed

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