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Case Reports
. 2020 Nov 12;9(1):213-219.
doi: 10.1002/ccr3.3501. eCollection 2021 Jan.

Reconstruction of intraoral oncologic surgical defects with Integra® bilayer wound matrix

Akanksha Srivastava  1 , Anastasios Maniakas  2 , Jeffrey Myers  2 , Mark S Chambers  3 , Richard Cardoso  3
Affiliations
Case Reports

Reconstruction of intraoral oncologic surgical defects with Integra® bilayer wound matrix

Akanksha Srivastava et al. Clin Case Rep. .

Abstract

Utilization of biologic skin substitutes for the management of soft tissue defects as an alternative to autologous skin grafts has expanded over the past 2 decades. The purpose of this case series study was to report our experience with Integra® bilayer wound matrix for reconstruction of intraoral oncologic defects. Case records of 6 patients with intraoral oncologic defects reconstructed with Integra® bilayer wound matrix were retrospectively reviewed. The surgical defect location, size, and time to removal of surgical splint varied. Clinically, normal oral epithelialization was noted for all patients. One patient demonstrated a small area of dehiscence and bone exposure after adjuvant radiation therapy which resolved with minimal intervention. Integra bilayer wound matrix is a viable and versatile option for reconstruction of intraoral oncologic surgical defects. Further exploration of wound healing with Integra® matrix, surgical techniques, and cost-effectiveness is advocated.

Keywords: biosynthetic skin substitutes; oral cancer; oral reconstruction; wound healing.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
(Case 1): A, Surgical defect following infrastructure maxillectomy, B, Integra® bilayer wound matrix sutured to surrounding oral mucosa, and C, relined surgical stent with ligature wires
Figure 2
Figure 2
(Case 1): A, Silicone sheet of Integra® matrix after removal of surgical stent 1 wk postoperatively, B, relined interim obturator, and C, 2‐mo postoperative healing with complete closure of oroantral fistula
Figure 3
Figure 3
(Case 2): A, Surgical defect following wide local excision of buccal mucosa, B, Integra® bilayer wound matrix sutured to surrounding oral mucosa, C, oral bolster secured to underlying tissues, and D, 3 mo postoperative healing with maximum mouth opening within normal limits
Figure 4
Figure 4
(Case 3): A, Surgical defect following wide local excision of the right maxillary gingiva and buccal mucosa, B, Integra®bilayer wound matrix sutured to surrounding oral mucosa, and C, exposed bony sequestrum after radiation therapy
Figure 5
Figure 5
(Case 4): A, Surgical defect following marginal mandibulectomy and wide local excision of anterior floor of the mouth, B, Integra® bilayer wound matrix sutured to surrounding oral mucosa, and C, 2‐mo postoperative healing with normal movable mucosa
Figure 6
Figure 6
(Case 5): A, Surgical defect following wide local excision of left maxillary gingiva, B, Integra® bilayer wound matrix sutured to surrounding gingiva and upper lip with perforations for locator abutments, and C, 2‐mo postoperative healing
Figure 7
Figure 7
(Case 6): A, Surgical defect following partial glossectomy, B, 2‐month postoperative healing with excellent contralateral and protrusive tongue movement
See this image and copyright information in PMC

References

    1. Janis JE, Kwon RK, Attinger CE. The new reconstructive ladder: modifications to the traditional model. Plast Reconstr Surg. 2011;127(suppl 1):205S‐S212. - PubMed
    1. Jones I, Currie K, Martin R. A guide to biological skin substitutes. Br J Plast Surg. 2002;55(3):185‐193. - PubMed
    1. Simman R. Wound closure and the reconstructive ladder in plastic surgery. J Am Col Certif Wound Spec. 2009;1(1):6‐11. - PMC - PubMed
    1. Schramm VL Jr, Johnson JT, Myers EN. Skin grafts and flaps in oral cavity reconstruction. Arch Otolaryngol. 1983;109(3):175‐177. - PubMed
    1. Logemann JA, Bytell DE. Swallowing disorders in three types of head and neck surgical patients. Cancer. 1979;44(3):1095‐1105. - PubMed

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