Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 4:2020:6831791.
doi: 10.1155/2020/6831791. eCollection 2020.

Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults

Gilberto Santos Morais Junior  1 , Diego Ignacio Valenzuela Perez  2 , Audrey Cecília Tonet-Furioso  3 , Lucy Gomes  3 , Karla Helena Coelho Vilaça  3 , Vicente Paulo Alves  3 , Clayton Franco Moraes  1   3 , Otávio Toledo Nóbrega  1   4
Affiliations

Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults

Gilberto Santos Morais Junior et al. J Aging Res. .

Abstract

Methods: One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry.

Results: Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08-6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16-7.05; p=0.022).

Conclusions: Our study shows a strong negative correlation of IL-6 levels with Fried's frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
A schematic drawing of the sample. NF = nonfrail and F = frail.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Megale R. Z., Ferreira M. L., Ferreira P. H., et al. Association between pain and the frailty phenotype in older men: longitudinal results from the Concord Health and Ageing in Men Project (CHAMP) Age and Ageing. 2018;47(3):381–387. doi: 10.1093/ageing/afy012. - DOI - PubMed
    1. Morais Junior G. S., Souza V. C., Machado-Silva W., et al. Resistance training modulates the humoral inflammatory (but not the DNA methylation) profile of diabetic older adults using metformin. Neuroimmunomodulation. 2019;26:1–8. - PubMed
    1. Scott D., Seibel M., Cumming R., et al. Sarcopenic obesity and its temporal associations with changes in bone mineral density, incident falls, and fractures in older men: the concord health and ageing in men project. Journal of Bone and Mineral Research. 2017;32(3):575–583. doi: 10.1002/jbmr.3016. - DOI - PubMed
    1. Fried L. P., Tangen C. M., Walston J., et al. Frailty in older adults: evidence for a phenotype. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2001;56(3):146–156. doi: 10.1093/gerona/56.3.m146. - DOI - PubMed
    1. Pivetta N. R. S., Marincolo J. C. S., Neri A. L., Aprahamian I., Yassuda M. S., Borim F. S. A. Multimorbidity, frailty and functional disability in octogenarians: a structural equation analysis of relationship. 9Archives of Gerontology and Geriatrics. 2019;86103931 - PubMed