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. 2020 Nov 4:2020:6831791.
doi: 10.1155/2020/6831791. eCollection 2020.

Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults

Gilberto Santos Morais Junior  1 , Diego Ignacio Valenzuela Perez  2 , Audrey Cecília Tonet-Furioso  3 , Lucy Gomes  3 , Karla Helena Coelho Vilaça  3 , Vicente Paulo Alves  3 , Clayton Franco Moraes  1   3 , Otávio Toledo Nóbrega  1   4
Affiliations

Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried's Frailty among Very Old Adults

Gilberto Santos Morais Junior et al. J Aging Res. .

Abstract

Methods: One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry.

Results: Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, serum levels of IL-6 were comparatively augmented among the very old participants with reduced grip strength (OR = 3.299; 95% CI 1.08-6.09; p=0.032) and among those with slow walk speed (OR = 2.460; 95% CI 1.16-7.05; p=0.022).

Conclusions: Our study shows a strong negative correlation of IL-6 levels with Fried's frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
A schematic drawing of the sample. NF = nonfrail and F = frail.
See this image and copyright information in PMC

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