Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer

Wenhua Liang¹, Kaican Cai², Chun Chen³, Haiquan Chen⁴, Qixun Chen⁵, Junke Fu⁶, Jian Hu⁷, Tao Jiang⁸, Wenjie Jiao⁹, Shuben Li¹, Changhong Liu¹⁰, Deruo Liu¹¹, Wei Liu¹², Yang Liu¹³, Haitao Ma¹⁴, Xiaojie Pan¹⁵, Guibin Qiao¹⁶, Hui Tian¹⁷, Li Wei¹⁸, Yi Zhang¹⁹, Song Zhao²⁰, Xiaojing Zhao²¹, Chengzhi Zhou¹, Yuming Zhu²², Ran Zhong¹, Feng Li¹, Rafael Rosell²³, Mariano Provencio²⁴, Erminia Massarelli²⁵, Mara B Antonoff²⁶, Toyoaki Hida²⁷, Marc de Perrot²⁸, Steven H Lin²⁹, Massimo Di Maio³⁰, Antonio Rossi³¹, Dirk De Ruysscher³², Robert A Ramirez³³, Wolfram C M Dempke³⁴, D Ross Camidge³⁵, Nicolas Guibert³⁶, Raffaele Califano³⁷, Qi Wang³⁸, Shengxiang Ren³⁹, Caicun Zhou³⁹, Jianxing He¹

Affiliations

¹ Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou, China.
² Nanfang Hospital, Guangzhou, China.
³ Fujian Medical University Union Hospital, Fuzhou, China.
⁴ Fundan University Shanghai Cancer Center, Shanghai, China.
⁵ Zhejiang Cancer Hospital, Hangzhou, China.
⁶ The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
⁷ The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.
⁸ Tangdu Hospital, Xi'an, China.
⁹ The Affiliated Hospital of Qingdao University, Qingdao, China.
¹⁰ The Second Hospital of Dalian Medical University, Dalian, China.
¹¹ China-Japan Friendship Hospital, Beijing, China.
¹² The First Bethune Hospital of Jilin University, Changchun, China.
¹³ Chinese PLA General Hospital, Beijing, China.
¹⁴ The Affiliated Hospital of Soochow University, Suzhou, China.
¹⁵ Fujian Provincial Hospital, Fuzhou, China.
¹⁶ Guangdong Provincial People's Hospital, Guangzhou, China.
¹⁷ Qilu Hospital of Shandong University, Ji'nan, China.
¹⁸ Henan Provincial People's Hospital, Zhengzhou, China.
¹⁹ Xuanwu Hospital Capital Medical University, Beijing, China.
²⁰ The Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
²¹ Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
²² Shanghai Pulmonary Hospital, Shanghai, China.
²³ Department of Medical Oncology, University of Barcelona, Hospital de Badalona Germans Trias i Pujol, Barcelona, Spain.
²⁴ Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
²⁵ City of Hope National Cancer Center, Duarte, CA, USA.
²⁶ Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²⁷ Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
²⁸ Toronto Mesothelioma Research Program, Toronto General Hospital, Toronto, ON, Canada.
²⁹ Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
³⁰ Department of Oncology, University of Turin/Division of Medical Oncology, Ordine Mauriziano Hospital, Turin, Italy.
³¹ Oncology Center of Excellence, Therapeutic Science & Strategy Unit, IQVIA, Milan, Italy.
³² Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
³³ Department of Internal Medicine, Section of Hematology/Oncology, Ochsner Medical Center, Kenner, LA, USA.
³⁴ Department of Hematology and Oncology, University Medical School, Munich, Germany.
³⁵ Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³⁶ Thoracic Oncology Department, Larrey Hospital, University Hospital of Toulouse, Toulouse, France.
³⁷ Department of Medical Oncology, The Christie NHS Foundation Trust, and Division of Cancer Sciences, The University of Manchester, Manchester, UK.
³⁸ Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
³⁹ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

PMID: 33489828
PMCID: PMC7815365
DOI: 10.21037/tlcr-2020-63

Review

Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer

Wenhua Liang et al. Transl Lung Cancer Res. 2020 Dec.

. 2020 Dec;9(6):2696-2715.

doi: 10.21037/tlcr-2020-63.

Authors

Affiliations

¹ Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou, China.
² Nanfang Hospital, Guangzhou, China.
³ Fujian Medical University Union Hospital, Fuzhou, China.
⁴ Fundan University Shanghai Cancer Center, Shanghai, China.
⁵ Zhejiang Cancer Hospital, Hangzhou, China.
⁶ The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
⁷ The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.
⁸ Tangdu Hospital, Xi'an, China.
⁹ The Affiliated Hospital of Qingdao University, Qingdao, China.
¹⁰ The Second Hospital of Dalian Medical University, Dalian, China.
¹¹ China-Japan Friendship Hospital, Beijing, China.
¹² The First Bethune Hospital of Jilin University, Changchun, China.
¹³ Chinese PLA General Hospital, Beijing, China.
¹⁴ The Affiliated Hospital of Soochow University, Suzhou, China.
¹⁵ Fujian Provincial Hospital, Fuzhou, China.
¹⁶ Guangdong Provincial People's Hospital, Guangzhou, China.
¹⁷ Qilu Hospital of Shandong University, Ji'nan, China.
¹⁸ Henan Provincial People's Hospital, Zhengzhou, China.
¹⁹ Xuanwu Hospital Capital Medical University, Beijing, China.
²⁰ The Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
²¹ Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
²² Shanghai Pulmonary Hospital, Shanghai, China.
²³ Department of Medical Oncology, University of Barcelona, Hospital de Badalona Germans Trias i Pujol, Barcelona, Spain.
²⁴ Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
²⁵ City of Hope National Cancer Center, Duarte, CA, USA.
²⁶ Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²⁷ Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
²⁸ Toronto Mesothelioma Research Program, Toronto General Hospital, Toronto, ON, Canada.
²⁹ Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
³⁰ Department of Oncology, University of Turin/Division of Medical Oncology, Ordine Mauriziano Hospital, Turin, Italy.
³¹ Oncology Center of Excellence, Therapeutic Science & Strategy Unit, IQVIA, Milan, Italy.
³² Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
³³ Department of Internal Medicine, Section of Hematology/Oncology, Ochsner Medical Center, Kenner, LA, USA.
³⁴ Department of Hematology and Oncology, University Medical School, Munich, Germany.
³⁵ Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³⁶ Thoracic Oncology Department, Larrey Hospital, University Hospital of Toulouse, Toulouse, France.
³⁷ Department of Medical Oncology, The Christie NHS Foundation Trust, and Division of Cancer Sciences, The University of Manchester, Manchester, UK.
³⁸ Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
³⁹ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

PMID: 33489828
PMCID: PMC7815365
DOI: 10.21037/tlcr-2020-63

No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tlcr-2020-63). The authors have no conflicts of interest to declare. The authors have no conflicts of interest to declare.

References

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424. 10.3322/caac.21492 - DOI - PubMed
1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016;66:115-32. 10.3322/caac.21338 - DOI - PubMed
1. Molina JR, Yang P, Cassivi SD, et al. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008;83:584-94. 10.1016/S0025-6196(11)60735-0 - DOI - PMC - PubMed
1. Arriagada R, Bergman B, Dunant A, et al. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004;350:351-60. 10.1056/NEJMoa031644 - DOI - PubMed
1. Winton T, Livingston R, Johnson D, et al. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med 2005;352:2589-97. 10.1056/NEJMoa043623 - DOI - PubMed

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Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer

Affiliations

Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer

Authors

Affiliations

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources