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Review
. 2021 Jan 7:10:607607.
doi: 10.3389/fonc.2020.607607. eCollection 2020.

Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer

Zeeshan Javed  1 , Muhammad Javed Iqbal  2 , Amna Rasheed  3 , Haleema Sadia  4 , Shahid Raza  1 , Asma Irshad  5 , Wojciech Koch  6 , Wirginia Kukula-Koch  7 , Anna Głowniak-Lipa  8 , William C Cho  9 , Javad Sharifi-Rad  10   11
Affiliations
Review

Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer

Zeeshan Javed et al. Front Oncol. .

Abstract

Hedgehog (Hh) signaling aberrations trigger differentiation and proliferation in colorectal cancer (CRC). However, the current approaches which inhibit this vital cellular pathway provoke some side effects. Therefore, it is necessary to look for new therapeutic options. MicroRNAs are small molecules that modulate expression of the target genes and can be utilized as a potential therapeutic option for CRC. On the other hand, nanoformulations have been implemented in the treatment of plethora of diseases. Owing to their excessive bioavailability, limited cytotoxicity and high specificity, nanoparticles may be considered as an alternative drug delivery platform for the Hh signaling mediated CRC. This article reviews the Hh signaling and its involvement in CRC with focus on miRNAs, nanoformulations as potential diagnostic/prognostic and therapeutics for CRC.

Keywords: Hedgehog signaling; colorectal cancer; miRNAs; nanoformulations; nanoparticle; therapeutics.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Therapeutic potential of miRNA inhibitors by targeting aberrant signaling cascades.
Figure 2
Figure 2
miRNAs targeting SMO oncogenic hedgehog pathway to induce apoptosis in CRC.
Figure 3
Figure 3
Molecular interplay between several miRNAs and their downstream target genes to induce apoptosis.
Figure 4
Figure 4
Schematic illustration of nanotherapeutic components.
Figure 5
Figure 5
Schematical representation the passage of oral nanotherapeutics to treat colon cancer.
See this image and copyright information in PMC

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