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Review
. 2020 Dec 16;8(1):86-132.
doi: 10.3934/Neuroscience.2021005. eCollection 2021.

The biological pathways of Alzheimer disease: a review

Marco Calabrò  1 , Carmela Rinaldi  1 , Giuseppe Santoro  1 , Concetta Crisafulli  1
Affiliations
Review

The biological pathways of Alzheimer disease: a review

Marco Calabrò et al. AIMS Neurosci. .

Abstract

Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with β-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.

Keywords: Alzheimer disease; biological pathways; immune system; oxidative stress.

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Conflict of interest statement

Conflicts of interest: The authors declare there are no conflicts of interest.

Figures

Figure 1.
Figure 1.. Graphical view of pathways connections.
See this image and copyright information in PMC

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