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. 2020 Dec 22:22:100306.
doi: 10.1016/j.ensci.2020.100306. eCollection 2021 Mar.

Posterior reversible encephalopathy syndrome and COVID-19: A series of 6 cases from Lombardy, Italy

Antonio Colombo  1 , Filippo Martinelli Boneschi  2 , Sandro Beretta  3 , Nereo Bresolin  2 , Maurizio Versino  4 , Lorenzo Lorusso  5 , Diego Spagnoli  6 , Giulia Nastasi  3 , Davide Vallauri  3 , Stefania Rota  3 , Maria Repaci  3 , Massimo Ferrarini  3 , Mattia Pozzato  2 , Lucia Princiotta Cariddi  4 , Payam Tabaee Damavandi  4 , Federico Carimati  4 , Paola Banfi  4 , Alessandro Clemenzi  4 , Margherita Marelli  4 , Andrea Giorgianni  4 , Gabriele Vinacci  4 , Marco Mauri  4 , Paola Melzi  5 , Maria Di Stefano  5 , Antonio Tetto  5 , Margherita Canesi  6 , Andrea Salmaggi  7
Affiliations

Posterior reversible encephalopathy syndrome and COVID-19: A series of 6 cases from Lombardy, Italy

Antonio Colombo et al. eNeurologicalSci. .

Abstract

Posterior reversible encephalopathy cases are increasingly being reported in patients affected by COVID-19, but the largest series so far only includes 4 patients. We present a series of 6 patients diagnosed with PRES during COVID-19 hospitalized in 5 Centers in Lombardia, Italy. 5 out of the 6 patients required intensive care assistence and seizures developed at weaning from assisted ventilation. 3 out of 6 patients underwent cerebrospinal fluid analysis which was normal in all cases, with negative PCR for Sars-CoV-2 genome search. PRES occurrence may be less rare than supposed in COVID-19 patients and a high suspicion index is warranted for prompt diagnosis and treatment.

Keywords: COVID-19; PRES; Seizures.

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Figures

Fig. 1
Fig. 1
FLAIR sequences of brain MRI.
See this image and copyright information in PMC

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