Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Jan 20;5(2):e525.
doi: 10.1097/HS9.0000000000000525. eCollection 2021 Feb.

Reshaping Erythrophagocytosis and Iron Recycling by Reticuloendothelial Macrophages

Francesca Vinchi  1   2 , S Zebulon Vance  1
Affiliations
Editorial

Reshaping Erythrophagocytosis and Iron Recycling by Reticuloendothelial Macrophages

Francesca Vinchi et al. Hemasphere. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Novel model of erythrophagocytosis. Upon entry in the spleen, erythrocytes flow through red pulp sinuses (1). The splenic architecture allows deformable healthy RBCs to pass through the web-like structure of red pulp sinuses and selectively retains senescent RBCs (2). While young RBCs leave the spleen and re-enter circulation (3), aged RBCs are captured through the interaction of laminin-α5 on the extracellular matrix with Lu/BCAM on aged RBC membrane and undergo shear stress-induced shrinkage and hemolysis (4). Red pulp macrophages phagocytize ghost remnants of aged RBCs, while Hb and heme content released in the extracellular space is scavenged by haptoglobin and hemopexin that facilitate macrophage-mediated iron recycling through receptor-mediated endocytosis (5). Hb = hemoglobin; Lu/BCAM = Lutheran blood group and basal cell adhesion molecule; RBC = red blood cell.
See this image and copyright information in PMC

References

    1. Mebius RE, Kraal G. Structure and function of the spleen. Nat Rev Immunol. 2005; 5:606–616 - PubMed
    1. Klei TRL, Dalimot J, Nota B, et al. . Hemolysis in the spleen drives erythrocyte turnover. Blood. 2020; 136:1579–1589 - PubMed
    1. Loegering DJ, Commins LM, Minnear FL, et al. . Effect of Kupffer cell phagocytosis of erythrocytes and erythrocyte ghosts on susceptibility to endotoxemia and bacteremia. Infect Immun. 1987; 55:2074–2080 - PMC - PubMed
    1. Mellman IS, Plutner H, Steinman RM, et al. . Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis. J Cell Biol. 1983; 96:887–895 - PMC - PubMed
    1. Gottlieb Y, Topaz O, Cohen LA, et al. . Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro. Haematologica. 2012; 97:994–1002 - PMC - PubMed

Publication types

LinkOut - more resources