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. 2022 Jun;122(3):641-646.
doi: 10.1007/s13760-020-01566-1. Epub 2021 Jan 24.

Employment status of patients with Charcot-Marie-Tooth type 1A

Bogdan Bjelica  1 , Marija Brankovic  2 , Ivo Bozovic  2 , Aleksa Palibrk  2 , Aleksandra Kacar  2 , Vidosava Rakocevic-Stojanovic  2
Affiliations

Employment status of patients with Charcot-Marie-Tooth type 1A

Bogdan Bjelica et al. Acta Neurol Belg. 2022 Jun.

Abstract

Previous studies showed that being unemployed is associated with lower quality of life in patients with Charcot-Marie-Tooth type 1A (CMT1A). The aim of this study was to assess the differences between CMT1A patients capable of working and CMT1A patients incapable of working due to CMT1A. Forty-four patients with genetically confirmed CMT1A were included. Medical Research Council (MRC) Sum Score, Charcot-Marie-Tooth Neuropathy Score (CMTNS), CMT Examination Score (CMTES), Overall Neuropathy Limitations Scale (ONLS), Beck Depression Inventory (BDI), Krupp's Fatigue Severity Scale (FSS), and Falls Efficacy Score (FES) were used. Whole cohort was divided into two groups: 1. CMT1A patients capable of working (employed and unemployed not due to CMT) and 2. CMT1A patients incapable of working due to CMT1A (unemployed due to CMT and retired due to CMT). At time of testing, 38.6% patients were employed, 13.6% were unemployed due to CMT, 6.8% were unemployed but not due to CMT, and 40.9% were retired early due to disability caused by CMT. Patients retired due to CMT1A at the age of 43 ± 10 years. ONLS total score and physical work appeared as significant independent predictors of being incapable of working due to CMT1A. Patients incapable of working were almost four times more likely to have fatigue (OR = 3.7, 95% CI 1.0-13.1, p < 0.05) and 11 times more likely to have fear of falling (OR = 11.0, 95% CI 2.0-59.7, p < 0.01). Patients with more severe functional disability and physical type of job were most likely incapable of working due to CMT1A. Incapability of working was associated with fatigue and fear of falling.

Keywords: Charcot-Marie-Tooth type 1A; Early retirement; Employment status; Fatigue; Predictors.

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References

    1. Ramchandren S (2017) Charcot-Marie-Tooth disease and other genetic polyneuropathies. Continuum 23(5):1360–1377
    1. Braathen GJ, Sand JC, Lobato A, Høyer H, Russell MB (2011) Genetic epidemiology of Charcot-Marie-Tooth in the general population. Eur J Neurol 18:39–48 - DOI
    1. Lupski JR, De Oca-Luna RM, Slaugenhaupt S et al (1991) DNA duplication associated with Charcot-Marie-Tooth disease type 1A. Cell 66:219–232 - DOI
    1. Cordeiro JL, Marques W, Hallak JE, Osório FL (2014) Charcot-Marie-Tooth disease, psychiatric indicators and quality of life: a systematic review. ASN Neuro 6(3):185–192 - DOI
    1. Vinci P, Serrao M, Millul A, Deidda A, De Santis F, Capici S, Martini D, Pierelli F, Santilli V (2005) Quality of life in patients with Charcot-Marie-Tooth disease. Neurology 65(6):922–924 - DOI

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