Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar;61(3):660-664.
doi: 10.1111/trf.16272. Epub 2021 Jan 25.

Transfusion management for children supported by extracorporeal membrane oxygenation

Oliver Karam  1 , Marianne E Nellis  2
Affiliations
Review

Transfusion management for children supported by extracorporeal membrane oxygenation

Oliver Karam et al. Transfusion. 2021 Mar.

Abstract

Due to the patients' underlying illness, in combination with circuit-induced coagulopathy, as well as PLT dysfunction, children supported by ECMO are a risk of receiving large volumes of blood components. Given the increasing use of modified blood products and newer biologics, it is unknown whether these products have equal efficacy and safety, in ECMO. The majority of guidance for transfusion therapy is based on expert opinion alone, and research on indications for RBC, plasma, and PLT transfusions for children on ECMO should be a priority.

PubMed Disclaimer

References

REFERENCES

    1. Pediatric Cardiac Failure. Extracorporeal Life Support Organization. c2021. Accessed January 3, 2021. http://www.elso.org/resources/guidelines.aspx.
    1. Dalton HJ, Reeder R, Garcia-Filion P, et al. Factors associated with bleeding and thrombosis in children receiving extracorporeal membrane oxygenation. Am J Respir Crit Care Med. 2017;196:762-771.
    1. Wong JJ, Lam JC, Mok YH, Lee JH. Anticoagulation in extracorporeal membrane oxygenation. J Emerg Crit Care Med. 2018;2:2. Available from: https://urldefense.proofpoint.com/v2/url?u=http-3A__jeccm.amegroups.com_....
    1. Bembea MM, Annich G, Rycus P, Oldenburg G, Berkowitz I, Pronovost P. Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: An international survey. Pediatr Crit Care Med. 2013;14:e77-e84.
    1. Qin CX, Yesantharao LV, Merkel KR, et al. Blood utilization and clinical outcomes in extracorporeal membrane oxygenation patients. Anesth Analg. 2020;131(3):901-908.

LinkOut - more resources