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Randomized Controlled Trial
. 2021 Feb;29(2):359-369.
doi: 10.1002/oby.23078.

Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial

Jarle Berge  1   2   3 , Jøran Hjelmesaeth  1   4 , Jens K Hertel  1 , Espen Gjevestad  1   2   5 , Milada Cvancarova Småstuen  1 , Line Kristin Johnson  1 , Catia Martins  6   7 , Eivind Andersen  8 , Jan Helgerud  9   10 , Øyvind Støren  3   8
Affiliations
Randomized Controlled Trial

Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial

Jarle Berge et al. Obesity (Silver Spring). 2021 Feb.

Abstract

Objective: This study aimed to compare the effects of two aerobic exercise programs of different intensities on energy expenditure.

Methods: This was a single-center randomized controlled trial of patients with severe obesity allocated to a 24-week moderate-intensity continuous training (MICT) program or a combined MICT with high-intensity interval training (HIIT/MICT) program. The primary outcome was energy expenditure during exercise (EEDE). Secondary outcomes included resting metabolic rate, cardiorespiratory fitness, and body composition.

Results: A total of 82 (56% females) patients were screened, and 71 (55% females) patients were allocated to HIIT/MICT (n = 37) or MICT (n = 34). Per-protocol analysis showed that EEDE increased by 10% (95% CI: 3%-17%) in the HIIT/MICT group (n = 16) and 7.5% (95% CI: 4%-10%) in the MICT group (n = 24), with no differences between groups. In the 8- to 16- week per-protocol analysis, the HIIT/MICT group had a significantly larger increase in EEDE compared with the MICT group. Resting metabolic rate remained unchanged in both groups. HIIT/MICT and MICT were associated with significant weight loss of 5 kg and 2 kg, respectively.

Conclusions: Patients completing a 24-week combined HIIT/MICT program did not achieve a higher EEDE compared with those who completed a 24-week MICT program. The HIIT/MICT group experienced, on average, a 3-kg-larger weight loss than the MICT group.

Trial registration: ClinicalTrials.gov NCT02311738.

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Conflict of interest statement

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Timeline for visit and training. HIIT, high‐intensity interval training; MICT, moderate‐intensity continuous training.
Figure 2
Figure 2
Flowchart. HIIT, high‐intensity interval training; ITT, intention‐to‐treat principle; MICT, moderate‐intensity continuous training.
Figure 3
Figure 3
Energy expenditure during exercise (kcal * h−1) by exercise group at baseline and at 8‐week, 16‐week, and 24‐week follow‐up. Values are presented as estimated means (95% CI) (per‐protocol). Moderate‐intensity continuous training (MICT) group in red dots and combined high‐intensity interval training and moderate‐intensity continuous training (HIIT/MICT) group in blue squares.
Figure 4
Figure 4
Resting metabolic rate (kcal * d−1) by exercise group at baseline and at 8‐week, 16‐week, and 24‐ week follow‐up. Value are presented as estimated means (95% CI) (per‐protocol). Moderate‐intensity continuous training (MICT) group in red dots and combined high‐intensity interval training and moderate‐intensity continuous training (HIIT/MICT) group in blue squares.
Figure 5
Figure 5
Maximum volume of oxygen consumed (VO2max; L * min−1) by exercise group at baseline and at 8‐week, 16‐week, and 24‐week follow‐up. Values are presented as estimated means (95% CI) (per‐protocol). Moderate‐intensity continuous training (MICT) group in red dots and combined high‐intensity interval training and moderate‐intensity continuous training (HIIT/MICT) group in blue squares.
See this image and copyright information in PMC

References

    1. Berge J, Storen O, Hertel JK, Gjevestad E, Smastuen MC, Hjelmesaeth J. Associations between cardiorespiratory fitness and weight loss in patients with severe obesity undergoing an intensive lifestyle intervention program: retrospective cohort study. BMC Endocr Disord 2019;19:69. doi:10.1186/s12902-019-0394-z - DOI - PMC - PubMed
    1. de Souza SA, Faintuch J, Sant'anna AF. Effect of weight loss on aerobic capacity in patients with severe obesity before and after bariatric surgery. Obes Surg 2010;20:871‐875. - PubMed
    1. Brien SE, Katzmarzyk PT, Craig CL, Gauvin L. Physical activity, cardiorespiratory fitness and body mass index as predictors of substantial weight gain and obesity: the Canadian physical activity longitudinal study. Can J Public Health 2007;98:121‐124. - PMC - PubMed
    1. Kantartzis K, Thamer C, Peter A, et al. High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non‐alcoholic fatty liver disease. Gut 2009;58:1281‐1288. - PubMed
    1. Dyrstad SM, Edvardsen E, Hansen BH, Anderssen SA. Waist circumference thresholds and cardiorespiratory fitness. J Sport Health Sci 2019;8:17‐22. - PMC - PubMed

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