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Review
. 2021 Jan;37(1):35-40.
doi: 10.1051/medsci/2020258. Epub 2021 Jan 25.

[Microbiota and IgA response homeostasis]

[Article in French]
Virginie Pascal  1 , Margaux Hiblot  1 , Batoul Wehbi  1 , Jean-Claude Aldigier  1 , Michel Cogné  2
Affiliations
Free article
Review

[Microbiota and IgA response homeostasis]

[Article in French]
Virginie Pascal et al. Med Sci (Paris). 2021 Jan.
Free article

Abstract
in English, French

Mucosal immunity has to deal with a patchy mix of commensal but also eventually pathogenic bugs. Immunoglobulins of the A class (IgA) are opposing to this duality a functional balance going from tolerance to protective response or even to hyper-inflammation. Recent reports have shown the binding of polyreactive natural IgA, but also of affinity maturated protective IgA to the commensal microbiota, to superantigens and also to vaccinal antigens. Diverse types of humoral responses thus altogether contribute to the homeostasis of mucosal immunity. Their knowledge has to be taken into consideration for defining strategies of immuno-intervention, for mucosal vaccination as much as for immunotherapy of chronic inflammatory bowel disease.

Title: Homéostasie de la réponse IgA et microbiote.

Abstract: L’immunité muqueuse s’établit en réponse à un ensemble de microorganismes qui sont surtout commensaux mais aussi, parfois, pathogènes. À cette dualité, les immunoglobulines de classe A (IgA) opposent une balance fonctionnelle allant de la tolérance à la protection, voire à une hyper-inflammation. Des travaux récents ont révélé la liaison d’IgA polyréactives naturelles ou, à l’inverse, d’IgA spécifiquement affines et protectrices, au microbiote commensal, mais aussi à des super-antigènes ou encore à des vaccins muqueux. Différents types de réponse humorale s’associent ainsi pour composer, ensemble, l’homéostasie de l’immunité muqueuse. Leur connaissance devrait ainsi influencer les stratégies de vaccination muqueuse et également les immunothérapies ciblant les maladies inflammatoires chroniques de l’intestin.

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