Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;93(1):210-4.
doi: 10.1111/j.1476-5381.1988.tb11423.x.

Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants

R G Lister  1 , D J Nutt
Affiliations

Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants

R G Lister et al. Br J Pharmacol. 1988 Jan.

Abstract

1. The proconvulsant effects of the imidazodiazepine Ro 15-4513, were investigated in mice by use of intravenous infusion of a variety of convulsant drugs. 2. Dose-response and time course studies of Ro 15-4513 against gamma-aminobutyric acid (GABA) antagonists were performed. On the basis of these studies a maximally effective dose of 5 mg kg-1 was administered 5 min before the determination of seizure thresholds in subsequent experiments. 3. Ro 15-4513 (5 mg kg-1) significantly lowered seizure thresholds to pentylenetetrazole, bicuculline and the convulsant benzodiazepine Ro 5-3663, but failed to alter seizure thresholds to picrotoxin, strychnine, caffeine and quipazine. 4. Ro 15-4513 significantly raised seizure threshold to the benzodiazepine receptor inverse agonist methyl 6,7-dimethoxy-4 ethyl-beta-carboline-3-carboxylate (DMCM). 5. These results are discussed in relation to other studies investigating the proconvulsant and alcohol-antagonizing effects of Ro 15-4513.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2246-50 - PubMed
    1. Science. 1986 Dec 5;234(4781):1243-7 - PubMed
    1. Neuropharmacology. 1980 Oct;19(10):1017-23 - PubMed
    1. Brain Res. 1981 Jul 20;216(2):399-408 - PubMed
    1. Eur J Pharmacol. 1981 May 8;71(2-3):287-95 - PubMed

MeSH terms