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. 2021 Jun;28(21):26653-26663.
doi: 10.1007/s11356-021-12422-x. Epub 2021 Jan 25.

Potential protective effects of Spirulina platensis on liver, kidney, and brain acrylamide toxicity in rats

May N Bin-Jumah  1 , Arwa Abdulkreem Al-Huqail  1 , Noha Abdelnaeim  2 , Mohamed Kamel  3 , Maged M A Fouda  4 , Mahmoud M A Abulmeaty  5 , Islam M Saadeldin  6 , Mohamed M Abdel-Daim  7   8
Affiliations

Potential protective effects of Spirulina platensis on liver, kidney, and brain acrylamide toxicity in rats

May N Bin-Jumah et al. Environ Sci Pollut Res Int. 2021 Jun.

Abstract

Acrylamide (AA) is a hazardous chemical that is widely used in industrial practices. Spirulina platensis (SP) is a blue green alga that is rich in bioactive compounds with many medicinal benefits. The aim of the present study was to evaluate the ameliorative effect of SP against AA toxicity in rats. Animals were divided into six groups: Group (1) was normal rats, groups (2) and (3) received SP at 500 and 1000 mg/kg BW orally respectively for 21 days, group (4) was administered 20 mg/kg BW AA daily for 14 days, while groups (5) and (6) were given orally SP at the same doses of groups (2) and (3), then AA at similar dose of group (4). Rats that received AA alone displayed markedly increased serum levels of liver enzymes (ALT, AST, and ALP), kidney function parameters (urea and creatinine), DNA damage marker (8-OHdG), and proinflammatory cytokines (IL-1β, IL-6, and TNF-α), compared to control rats. Furthermore, tissue analysis revealed marked increases in hepatic, renal, and brain MDA and NO, as well as marked reductions in the antioxidant biomarkers (GSH, GSH-Px, SOD, and CAT) in acrylamide-intoxicated rats. Spirulina ameliorated the alterations in serum biochemical parameters and reduced MDA and NO, as well as improved antioxidant biomarkers in AA-intoxicated rats in a dose-dependent manner. Our results show that SP has a powerful protective effect on serum biochemistry and liver, kidney, and brain antioxidant machinery in AA-intoxicated rats.

Keywords: Acrylamide; Inflammation; Oxidative stress; Rats; Spirulina platensis.

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References

    1. Abdel-Daim MM (2014) Pharmacodynamic interaction of Spirulina platensis with erythromycin in Egyptian Baladi bucks (Capra hircus). Small Ruminant Research 120:234–241 - DOI
    1. Abdel-Daim MM, Abuzead SM, Halawa SM (2013) Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats. Plos one 8:e72991 - DOI
    1. Abdel-Daim MM, Farouk SM, Madkour FF, AZAB SS (2015) Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis. Immunopharmacol Immunotoxicol 37:126–139 - DOI
    1. Abdel-Daim M, El-Bialy BE, Rahman HG, Radi AM, Hefny HA, Hassan AM (2016 Feb) Antagonistic effects of Spirulina platensis against sub-acute deltamethrin toxicity in mice: biochemical and histopathological studies. Biomed Pharmacother. 77:79–85. https://doi.org/10.1016/j.biopha.2015.12.003 - DOI
    1. Abdel-Daim MM, Abushouk AI, Alkhalf MI, Toraih EA, Fawzy MS, Ijaz H, Aleya L, Bungau SG (2018 Sep) Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats. Environ Sci Pollut Res Int. 25(27):27463–27470. https://doi.org/10.1007/s11356-018-2761-0 - DOI

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