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Comment
. 2021 Mar 1;14(3):364-365.
doi: 10.1016/j.molp.2021.01.012. Epub 2021 Jan 22.

HASTY moves to chromatin for miRNA production

Di Sun  1 , Xiuren Zhang  2
Affiliations
Comment

HASTY moves to chromatin for miRNA production

Di Sun et al. Mol Plant. .
No abstract available

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Figures

Figure 1.
Figure 1.. HST moves close to MIR loci for miRNA production.
Transcription of MIR loci is positively regulated by MED complexes. Pri-miRNAs are processed by DCL1-centered microprocessors to produce miRNAs, which are in turn exported from the nucleus through AGO1-RISC complex. Cambiagno and colleagues found that, through the interaction with MED complexes and DCL1, HST recruits DCL1 to MIR loci and facilitates the capture and processing of pri-miRNAs. HST is imported from cytoplasm to nucleus by IMPA-2 and exported to cytoplasm by RAN1 without mature miRNAs. The bona fide cargos of HST remain to be identified. MIR, MIR genes; MED, Mediator complex; DCL1, Dicer-Like 1; SE, Serrate; HYL1, Hyponastic Leaves 1; IMPA-2, Importin α Isoform 2; RAN1, Ras-Related Nuclear Protein 1; AGO1, Argonaute 1; EXPO1, Exportin 1.
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