Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;71(Pt A):101883.
doi: 10.1016/j.canep.2020.101883. Epub 2021 Jan 22.

Stage-specific incidence trends of renal cancers in the East of England, 1999-2016

Annie Herbert  1 , Matthew E Barclay  2 , Minjoung M Koo  3 , Brian Rous  4 , David C Greenberg  4 , Gary Abel  5 , Georgios Lyratzopoulos  6
Affiliations

Stage-specific incidence trends of renal cancers in the East of England, 1999-2016

Annie Herbert et al. Cancer Epidemiol. 2021 Apr.

Abstract

Objectives: To determine stage-specific time-trends in renal cancer incidence.

Methods: We used population-based East Anglia data 1999-2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation.

Results: Renal cancer incidence increased from 9.8-16.4 cases per 100,000 during 1999-2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07-1.12) during 1999-2010; and 1.03 (1.00-1.05) during 2011-2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98-1.00) during 2003-2016.

Conclusion: The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.

Keywords: Cancer; Diagnosis; Renal; Stage; Trends.

PubMed Disclaimer

Conflict of interest statement

AH, MEB, MMK, BR, DCG, GAA, and GL have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Age-standardised incidence of renal cancer (observed and fitted)*, overall and by stage at diagnosis, by sex. *Dashed lines estimated from five separate Poisson models (one for all cases, and one each for stage-specific cases) including main effect variables for sex, age group, deprivation, and year (segmented at 2010 for Stage I cases and 2003 for Stage IV cases). Exact model forms provided within Box S1. For 427 patients with missing values on stage, these values were imputed as described under ‘Multiple imputation’ in the Methods section.
See this image and copyright information in PMC

References

    1. Smittenaar C.R., Petersen K.A., Stewart K., Moitt N. Cancer incidence and mortality projections in the UK until 2035. Br. J. Cancer. 2016;115(9):1147–1155. - PMC - PubMed
    1. Znaor A., Lortet-Tieulent J., Laversanne M., Jemal A., Bray F. International variations and trends in renal cell carcinoma incidence and mortality. Eur. Urol. 2015;67(3):519–530. - PubMed
    1. Levi F., Lucchini F., Negri E., La Vecchia C. Declining mortality from kidney cancer in Europe. Ann. Oncol. 2004;15(7):1130–1135. - PubMed
    1. Jayson M., Sanders H. Increased incidence of serendipitously discovered renal cell carcinoma. Urology. 1998;51(2):203–205. - PubMed
    1. Hollingsworth J.M., Miller D.C., Daignault S., Hollenbeck B.K. Rising incidence of small renal masses: a need to reassess treatment effect. J. Natl. Cancer Inst. 2006;98(18):1331–1334. - PubMed

Publication types