Is the differential diagnosis of epilepsy and psychogenic nonepileptic seizures possible by assessing the neutrophil/lymphocyte ratio?

Abstract

Introduction: The neutrophil-to-lymphocyte ratio (NLR), which can be calculated directly from the complete blood count, is a parameter that can be accepted as an indicator of systemic inflammation. In this study, we tried to distinguish seizures from pseudo-seizures by evaluating the NLR value in the pre- and post-seizure period in epilepsy and psychogenic nonepileptic seizures (PNES).

Material and method: Of the 50 patients included in our study, 36 had epilepsy and 14 had PNES. Comparison of pre- and post-seizure values of leukocyte, neutrophil, and NLR values and heart rate were made between focal, generalized onset seizures, and PNES. The pre- and post-seizure NLR was assessed for each group.

Results: The number of leukocytes and neutrophils determined after the seizure was significantly higher in the group with generalized onset seizures compared to the PNES group. When the pre- and post-seizure leukocyte counts were examined in the generalized onset seizure group, it was observed that the post-seizure leukocyte count was significantly higher (p: <0.001). In our study, there were no differences in the ictal and postictal heart rates between the PNES and epilepsy groups, unlike previous studies. We found that the ictal heart rate was statistically higher than the preictal heart rate in the epilepsy group, as expected, but the differences in heart rate between PNES and epilepsy did not separate the groups in a meaningful way.

Conclusion: As a result of these examinations, we observed that patients with epilepsy with generalized and focal onset seizures had a significantly higher number of leukocytes in their post-seizure blood. However, pre- and post-seizure NLR could not help us, within this group of patients, to separate PNES from epileptic seizures.

Keywords: Epilepsy; Neutrophil-to-lymphocyte ratio; Psychogenic nonepileptic seizures.