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Review
. 2021 Jan 21;10(3):396.
doi: 10.3390/jcm10030396.

Local Treatment of Burns with Cell-Based Therapies Tested in Clinical Studies

Anna Paulina Domaszewska-Szostek  1 , Marta Olga Krzyżanowska  2 , Anna Maria Czarnecka  3 , Maria Siemionow  4
Affiliations
Review

Local Treatment of Burns with Cell-Based Therapies Tested in Clinical Studies

Anna Paulina Domaszewska-Szostek et al. J Clin Med. .

Abstract

Effective wound management is an important determinant of the survival and prognosis of patients with severe burns. Thus, novel techniques for timely and full closure of full-thickness burn wounds are urgently needed. The purpose of this review is to present the current state of knowledge on the local treatment of burn wounds (distinguishing radiation injury from other types of burns) with the application of cellular therapies conducted in clinical studies. PubMed search engine and ClinicalTrials.gov were used to analyze the available data. The analysis covered 49 articles, assessing the use of keratinocytes (30), keratinocytes and fibroblasts (6), fibroblasts (2), bone marrow-derived cells (8), and adipose tissue cells (3). Studies on the cell-based products that are commercially available (Epicel®, Keraheal™, ReCell®, JACE, Biobrane®) were also included, with the majority of reports found on autologous and allogeneic keratinocytes. Promising data demonstrate the effectiveness of various cell-based therapies; however, there are still scientific and technical issues that need to be solved before cell therapies become standard of care. Further evidence is required to demonstrate the clinical efficacy and safety of cell-based therapies in burns. In particular, comparative studies with long-term follow-up are critical.

Keywords: adipose tissue; burns; fibroblasts; keratinocytes; mesenchymal stem cells; radiation burns.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Cell therapy strategies for burn wound healing.
See this image and copyright information in PMC

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