Intraoperative radiotherapy for breast cancer: powerful evidence to change practice

Affiliations

¹ Division of Surgery and Interventional Science, University College London, London, UK. jayantvaidya@gmail.com.
² Division of Surgery and Interventional Science, University College London, London, UK.
³ Department of Biostatistics, University of Notre Dame, Fremantle, WA, Australia.
⁴ Department of Surgery, University of California, San Francisco, CA, USA.
⁵ , London, UK.
⁶ Department of Surgery, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
⁷ School of Surgery, University of Western Australia, Perth, WA, Australia.
⁸ University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
⁹ University Medical Center Freiburg, Freiburg, Germany.
¹⁰ Department of Clinical Oncology, University College London Hospitals, London, UK.

PMID: 33495552
PMCID: PMC7830040
DOI: 10.1038/s41571-021-00471-7

Comment

Intraoperative radiotherapy for breast cancer: powerful evidence to change practice

Jayant S Vaidya et al. Nat Rev Clin Oncol. 2021 Mar.

. 2021 Mar;18(3):187-188.

doi: 10.1038/s41571-021-00471-7.

Authors

Affiliations

¹ Division of Surgery and Interventional Science, University College London, London, UK. jayantvaidya@gmail.com.
² Division of Surgery and Interventional Science, University College London, London, UK.
³ Department of Biostatistics, University of Notre Dame, Fremantle, WA, Australia.
⁴ Department of Surgery, University of California, San Francisco, CA, USA.
⁵ , London, UK.
⁶ Department of Surgery, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
⁷ School of Surgery, University of Western Australia, Perth, WA, Australia.
⁸ University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
⁹ University Medical Center Freiburg, Freiburg, Germany.
¹⁰ Department of Clinical Oncology, University College London Hospitals, London, UK.

PMID: 33495552
PMCID: PMC7830040
DOI: 10.1038/s41571-021-00471-7

No abstract available

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Conflict of interest statement

J.S.V. has received research funding and honoraria from Photoelectron Corp and Carl Zeiss and has received travel support from Carl Zeiss. M. Bulsara has received travel support from Carl Zeiss. M. Baum has served on the scientific advisory board, has acted as a consultant of and received travel support from Carl Zeiss. M.A. has received travel support from Carl Zeiss. M. Bernstein has received travel support from Carl Zeiss. S. M. has received travel support from Carl Zeiss. C.S. has received travel support from Carl Zeiss. E.S. has received honoraria and travel support from Carl Zeiss. F.W. has received research funding and travel support from Carl Zeiss. J.S.T. has received travel support from Carl Zeiss.

Comment in

Reply to 'Intraoperative radiotherapy for breast cancer: powerful evidence to change practice'.
Sasieni PD, Sawyer EJ. Sasieni PD, et al. Nat Rev Clin Oncol. 2021 Mar;18(3):188-189. doi: 10.1038/s41571-021-00472-6. Nat Rev Clin Oncol. 2021. PMID: 33495551 No abstract available.

Comment on

Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.
Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Douek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams NR, Potyka I, Roberts N, Bernstein M, Brown D, Sperk E, Laws S, Sütterlin M, Corica T, Lundgren S, Holmes D, Vinante L, Bozza F, Pazos M, Le Blanc-Onfroy M, Gruber G, Polkowski W, Dedes KJ, Niewald M, Blohmer J, McCready D, Hoefer R, Kelemen P, Petralia G, Falzon M, Joseph DJ, Tobias JS. Vaidya JS, et al. BMJ. 2020 Aug 19;370:m2836. doi: 10.1136/bmj.m2836. BMJ. 2020. PMID: 32816842 Free PMC article. Clinical Trial.
Intraoperative radiotherapy for early breast cancer - insufficient evidence to change practice.
Sasieni PD, Sawyer EJ. Sasieni PD, et al. Nat Rev Clin Oncol. 2020 Dec;17(12):723-724. doi: 10.1038/s41571-020-00444-2. Nat Rev Clin Oncol. 2020. PMID: 33087894 Free PMC article.

References

1. Sasieni PD, Sawyer EJ. Intraoperative radiotherapy for early breast cancer — insufficient evidence to change practice. Nat. Rev. Clin. Oncol. 2020;17:723–724. doi: 10.1038/s41571-020-00444-2. - DOI - PMC - PubMed
1. Vaidya JS, et al. Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial. BMJ. 2020;370:m2836. doi: 10.1136/bmj.m2836. - DOI - PMC - PubMed
1. Coombs NJ, et al. Environmental and social benefits of the targeted intraoperative radiotherapy for breast cancer: data from UK TARGIT-A trial centres and two UK NHS hospitals offering TARGIT IORT. BMJ Open. 2016;6:e010703. doi: 10.1136/bmjopen-2015-010703. - DOI - PMC - PubMed
1. Taylor C, et al. Estimating the risks of breast cancer radiotherapy: evidence from modern radiation doses to the lungs and heart and from previous randomized trials. J. Clin. Oncol. 2017;35:1641–1649. doi: 10.1200/JCO.2016.72.0722. - DOI - PMC - PubMed
1. Darby SC, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N. Engl. J. Med. 2013;368:987–998. doi: 10.1056/NEJMoa1209825. - DOI - PubMed

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Intraoperative radiotherapy for breast cancer: powerful evidence to change practice

Affiliations

Intraoperative radiotherapy for breast cancer: powerful evidence to change practice

Authors

Affiliations

Conflict of interest statement

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References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

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Medical