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. 2021 Feb;27(2):624-627.
doi: 10.3201/eid2702.203874.

Azithromycin-Resistant Salmonella enterica Serovar Typhi AcrB-R717Q/L, Singapore

Sophie Octavia, Ka Lip Chew, Raymond T P Lin, Jeanette W P Teo

Azithromycin-Resistant Salmonella enterica Serovar Typhi AcrB-R717Q/L, Singapore

Sophie Octavia et al. Emerg Infect Dis. 2021 Feb.

Abstract

Global travel has led to intermittent importation of multidrug-resistant Salmonella enterica serovar Typhi into industrialized countries. We detected azithromycin-resistant Salmonella Typhi in Singapore, of which 2 isolates were likely locally acquired. Ongoing vigilance and surveillance to minimize the public health risk for this serious pathogen is needed.

Keywords: AcrB-R717Q/L; Salmonella enterica; Singapore; antimicrobial resistance; azithromycin; azithromycin-resistant isolates; bacteria; serovar Typhi; typhoid fever.

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Figures

Figure
Figure
Core single-nucleotide polymorphism phylogenetic tree of 15 genotype 4.3.1 Salmonella enterica serovar Typhi isolates tested for azithromycin resistance, Singapore. Isolates sequenced in this study were compared with other publicly available Salmonella Typhi genomes, indicated by their corresponding GenBank accession number obtained from Pathogenwatch (https://pathogen.watch) on the basis of 3,104 core-genome single-nucleotide polymorphisms. Azithromycin-resistant isolates analyzed in this study are indicated by asterisks (*). Salmonella Typhi CT18 was designated as the reference genome (blue). Genotype information obtained from the GenoTyphi tool (4) was included for all genomes, and country of isolation was added when available. The tree was illustrated by using iTOL version (8). Scale bar indicates nucleotide substitutions per site.
See this image and copyright information in PMC

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