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Comment
. 2020 Jul 1;319(1):L35-L36.
doi: 10.1152/ajplung.00170.2020.

Potential role for nitazoxanide in treating SARS-CoV-2 infection

Paulo Ricardo Martins-Filho  1 , José Antônio Barreto-Alves  2 , Ricardo Fakhouri  3
Affiliations
Comment

Potential role for nitazoxanide in treating SARS-CoV-2 infection

Paulo Ricardo Martins-Filho et al. Am J Physiol Lung Cell Mol Physiol. .
No abstract available

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Comment on

References

    1. Ashiru O, Howe JD, Butters TD. Nitazoxanide, an antiviral thiazolide, depletes ATP-sensitive intracellular Ca2+ stores. Virology 462-463: 135–148, 2014. doi:10.1016/j.virol.2014.05.015. - DOI - PubMed
    1. Gamiño-Arroyo AE, Guerrero ML, McCarthy S, Ramírez-Venegas A, Llamosas-Gallardo B, Galindo-Fraga A, Moreno-Espinosa S, Roldán-Aragón Y, Araujo-Meléndez J, Hunsberger S, Ibarra-González V, Martínez-López J, García-Andrade LA, Kapushoc H, Holley HP, Smolskis MC, Ruiz-Palacios GM, Beigel JH, Guerrero ML, Gamiño-Arroyo AE, Ramírez-Venegas A, Bautista N, Nolasco-Reza A, Llamosas-Gallardo B, Ortiz-Hernández AA, Andrade-Platas D, Estevez-Jimenez J, Galindo-Fraga A, Roa-Martínez B, Cruz-Gaona I, Aguilar-Cruz D, Moreno-Espinosa S, González-Matus M, Mendoza-Garcés L, Araujo-Meléndez J, Perea-Guzmán N, Sandoval-Gutiérrez A, Hernández-Ramírez D, Hernández-Sánchez PG, Roldán-Aragón YA, Davila-Cruz AN, Ibarra-González V, Martínez-López J, García-Andrade LA, Ruiz-Palacios GM, Beigel JH, Smolskis M, Hunsberger S, Sean McCarthy H, Grue L, Burge G, Cox R, Holley P Jr, Cristillo A, Nahed N, López W, Becerril-Ruiz EX, Quidgley P, Arroyo-Figueroa H; Mexico Emerging Infectious Diseases Clinical Research Network (LaRed) . Efficacy and safety of nitazoxanide in addition to standard of care for the treatment of severe acute respiratory illness. Clin Infect Dis 69: 1903–1911, 2019. doi:10.1093/cid/ciz100. - DOI - PMC - PubMed
    1. Haffizulla J, Hartman A, Hoppers M, Resnick H, Samudrala S, Ginocchio C, Bardin M, Rossignol J-F; US Nitazoxanide Influenza Clinical Study Group . Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial. Lancet Infect Dis 14: 609–618, 2014. doi:10.1016/S1473-3099(14)70717-0. - DOI - PMC - PubMed
    1. Hong SK, Kim HJ, Song CS, Choi IS, Lee JB, Park SY. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. Int Immunopharmacol 13: 23–27, 2012. doi:10.1016/j.intimp.2012.03.002. - DOI - PubMed
    1. Nieto-Torres JL, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Torres J, Aguilella VM, Enjuanes L. Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome. Virology 485: 330–339, 2015. doi:10.1016/j.virol.2015.08.010. - DOI - PMC - PubMed