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. 2021 Mar;383(3):1203-1208.
doi: 10.1007/s00441-020-03362-y. Epub 2021 Jan 26.

Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli

Emily Boucher  1 , Luke Brown  2 , Priyoshi Lahiri  3 , Eduardo R Cobo  4
Affiliations

Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli

Emily Boucher et al. Cell Tissue Res. 2021 Mar.

Abstract

Cathelicidins are small, cationic peptides produced by macrophages with protective effects against infection although their involvement in phagocytosis is not fully understood. This study demonstrates that fewer macrophages were recruited in mice genetically deficient in cathelicidin (Camp-/-) during acute Escherichia coli-induced peritonitis and those macrophages had impaired phagocytosis. These defects seem due to endogenous functions of murine cathelicidin (CRAMP) as phagocytosis was not improved by synthetic human cathelicidin (LL-37) in a murine phagocytic cell line. This knowledge contributes to understanding the function of cathelicidins in the recruitment and function of phagocytic cells and differential roles between endogenous and exogenous cathelicidins.

Keywords: Cathelicidin; Escherichia coli; Macrophage; Phagocytosis.

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