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Clinical Trial
. 2021 May;30(5):1491-1502.
doi: 10.1007/s11136-020-02738-5. Epub 2021 Jan 26.

Development of an EORTC questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumours: phase I-III

Quirien Oort  1 , Linda Dirven  2   3 , Sietske A M Sikkes  4   5   6 , Neil Aaronson  7 , Florien Boele  8   9 , Christine Brannan  10 , Jonas Egeter  11 , Robin Grant  12 , Martin Klein  13 , Irene Lips  14 , Yoshitaka Narita  15 , Hitomi Sato  15   16 , Monika Sztankay  11 , Günther Stockhammer  17 , Andrea Talacchi  18 , Bernard M J Uitdehaag  19 , Jaap C Reijneveld  19   20 , Martin J B Taphoorn  2   3 ; EORTC Quality of Life Group
Affiliations
Clinical Trial

Development of an EORTC questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumours: phase I-III

Quirien Oort et al. Qual Life Res. 2021 May.

Abstract

Purpose: Being able to function independently in society is an important aspect of quality of life. This ability goes beyond self-care, requires higher order cognitive functioning, and is typically measured with instrumental activities of daily living (IADL) questionnaires. Cognitive deficits are frequently observed in brain tumour patients, however, IADL is almost never assessed because no valid and reliable IADL measure is available for this patient group. Therefore, this measure is currently being developed.

Methods: This international multicentre study followed European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group module development guidelines. Three out of four phases are completed: phases (I) generation of items, (II) construction of the item list, and (III) pre-testing. This paper reports the item selection procedures and preliminary psychometric properties of the questionnaire. Brain tumour patients (gliomas and brain metastases), their informal caregivers, and health care professionals (HCPs) were included.

Results: Phase I (n = 44 patient-proxy dyads and 26 HCPs) generated 59 relevant and important activities. In phase II, the activities were converted into items. In phase III (n = 85 dyads), the 59 items were pre-tested. Item selection procedures resulted in 32 items. Exploratory factor analysis revealed a preliminary dimensional structure consisting of five scales with acceptable to excellent internal consistency (α = 0.73-0.94) and two single items. For three scales, patients with cognitive impairments had significantly more IADL problems than patients without impairments.

Conclusion: A phase IV validation study is needed to confirm the psychometric properties of the EORTC IADL-BN32 questionnaire in a larger international sample.

Keywords: Brain tumour; Daily functioning; IADL; Instrumental activities of daily living; Questionnaire.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Flowchart item selection phases I-III
Fig. 2
Fig. 2
Scree plot
See this image and copyright information in PMC

References

    1. Lawton MP, Brody EM. Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179–186. doi: 10.1093/geront/9.3_Part_1.179. - DOI - PubMed
    1. Passler JS, Kennedy RE, Clay OJ, et al. The relationship of longitudinal cognitive change to self-reported IADL in a general population. Aging, Neuropsychology, and Cognition. 2020;27(1):125–139. doi: 10.1080/13825585.2019.1597008. - DOI - PMC - PubMed
    1. Koster N, Knol DL, Uitdehaag BM, Scheltens P, Sikkes SA. The sensitivity to change over time of the Amsterdam IADL Questionnaire((c)) Alzheimers Dement. 2015;11(10):1231–1240. doi: 10.1016/j.jalz.2014.10.006. - DOI - PubMed
    1. Bosma I, Vos MJ, Heimans JJ, et al. The course of neurocognitive functioning in high-grade glioma patients1. Neuro-Oncology. 2007;9(1):53–62. doi: 10.1215/15228517-2006-012. - DOI - PMC - PubMed
    1. Oort Q, Taphoorn MJB, Sikkes SAM, Uitdehaag BMJ, Reijneveld JC, Dirven L. Evaluation of the content coverage of questionnaires containing basic and instrumental activities of daily living (ADL) used in adult patients with brain tumors. Journal of Neuro-oncology. 2019;143(1):1–13. doi: 10.1007/s11060-019-03136-9. - DOI - PMC - PubMed

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