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. 2021 Jan;15(1):51-59.
doi: 10.22074/ijfs.2021.6186. Epub 2021 Jan 19.

Synbiotic Supplementation Improves Metabolic Factors and Obesity Values in Women with Polycystic Ovary Syndrome Independent of Affecting Apelin Levels: A Randomized Double-Blind Placebo - Controlled Clinical Trial

Sima Darvishi  1 , Maryam Rafraf  2 , Mohammad Asghari-Jafarabadi  3   4 , Laya Farzadi  5
Affiliations

Synbiotic Supplementation Improves Metabolic Factors and Obesity Values in Women with Polycystic Ovary Syndrome Independent of Affecting Apelin Levels: A Randomized Double-Blind Placebo - Controlled Clinical Trial

Sima Darvishi et al. Int J Fertil Steril. 2021 Jan.

Abstract

Background: This research investigated the symbiotic supplement influences on serum glycemic indices and lipids as well as apelin rates and obesity values in polycystic ovary syndrome (PCOS) patients.

Materials and methods: A total of 68 obese or overweight patients (20-44 years old) with PCOS were enrolled to conduct a randomized double-blinded placebo-controlled clinical trial. A total of 34 people in the synbiotic group received a synbiotic supplement and 34 people in the placebo group received placebo, daily for 8 weeks. Fasting blood specimens, anthropometric measurements and dietary intake data were gathered three times during the study. The information was analyzed by independent t test, paired t test, analysis of covariance and chi-square test.

Results: Synbiotic supplementation significantly decreased serum fasting glucose (P=0.02), insulin (P=0.001), homeostatic model assessment for insulin resistance (IR, P=0.001), weight (P=0.02), body mass index (BMI, P=0.02), waist circumference (WC, P=0.01), hip circumference (HC, P=0.02), and waist-to-height ratio (WHtR, P=0.02) but significantly increased high-density lipoprotein (HDL) cholesterol (P=0.02) compared to the placebo. At the end of the trial, no significant differences were seen in serum total cholesterol, triglyceride (TG), low-density lipoprotein (LDL) cholesterol, or apelin levels as well as waist-to-hip ratio (WHR) between the two groups.

Conclusion: Synbiotic supplementation improved glycemic indices, lipid profile and obesity values in women with PCOS. These beneficial effects were not related with alterations in serum apelin levels (Registration number: IRCT20100408003664N19).

Keywords: Apelin; Metabolic Factors; Obesity; Polycystic Ovary Syndrome; Synbiotic.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig.1
Fig.1
Participants flow diagram.
See this image and copyright information in PMC

References

    1. Karakas SE. New biomarkers for diagnosis and management of polycystic ovary syndrome. Clin Chim Acta. 2017;471:248–253. - PubMed
    1. De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol. 2016;14(1):38–38. - PMC - PubMed
    1. Zhang J, Sun Z, Jiang S, Bai X, Ma C, Peng Q, et al. Probiotic bifidobacterium lactis v9 regulates the secretion of sex hormones in polycystic ovary syndrome patients through the gut-brain axis. Systems. 2019;4(2):e00017–19. - PMC - PubMed
    1. Baillargeon JP, Nestler JE, Ostlund RE, Apridonidze T, DiamantiKandarakis E. Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism. Hum Reprod. 2008;23(6):1439–1446. - PMC - PubMed
    1. Yousuf SD, Rashid F, Mattoo T, Shekhar C, Mudassar S, Zargar MA, et al. Does the oral contraceptive pill increase plasma intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and tumor necrosis factor-α levels in women with polycystic ovary syndrome: a pilot study. J Pediatr Adolesc Gynecol. 2017;30(1):58–62. - PubMed

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