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. 1977 Nov;119(5):1806-12.

Late acting T cell depression of high avidity IgG antibody secretion in the secondary response

R W Warren, J M Davie
  • PMID: 334971

Late acting T cell depression of high avidity IgG antibody secretion in the secondary response

R W Warren et al. J Immunol. 1977 Nov.

Abstract

Activated T lymphocytes (ATC) suppressed the expression of high avidity plaque-forming cells (PFC) in the secondary immune response when given in vivo 1 day before assay or when mixed in vitro with hyperimmune cells for 90 min before assay. This late acting suppression is a cell dose-dependent, carrier-spedific, T cell-mediated phenomenon. The target of this activity if probably the antibody-secreting cell.

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