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Comment
. 2021 Jan 25;56(2):156-158.
doi: 10.1016/j.devcel.2021.01.002. Epub 2021 Jan 25.

Nuclear Deformation Lets Cells Gauge Their Physical Confinement

Joseph T Long  1 , Jan Lammerding  2
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Free article
Comment

Nuclear Deformation Lets Cells Gauge Their Physical Confinement

Joseph T Long et al. Dev Cell. .
Free article

Abstract

How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migration, revealing the nucleus to serve as a central mechanosensor.

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  • The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior.
    Venturini V, Pezzano F, Català Castro F, Häkkinen HM, Jiménez-Delgado S, Colomer-Rosell M, Marro M, Tolosa-Ramon Q, Paz-López S, Valverde MA, Weghuber J, Loza-Alvarez P, Krieg M, Wieser S, Ruprecht V. Venturini V, et al. Science. 2020 Oct 16;370(6514):eaba2644. doi: 10.1126/science.aba2644. Science. 2020. PMID: 33060331
  • The nucleus acts as a ruler tailoring cell responses to spatial constraints.
    Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, Sáez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, González-Granado JM, Manel N, Lennon-Duménil AM, Müller DJ, Piel M. Lomakin AJ, et al. Science. 2020 Oct 16;370(6514):eaba2894. doi: 10.1126/science.aba2894. Science. 2020. PMID: 33060332 Free PMC article.

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