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. 2021 Jan 20;18(3):857.
doi: 10.3390/ijerph18030857.

Gender Differences in the Relationships among Metabolic Syndrome and Various Obesity-Related Indices with Nonalcoholic Fatty Liver Disease in a Taiwanese Population

I-Ting Lin  1 , Mei-Yueh Lee  1 , Chih-Wen Wang  2   3 , Da-Wei Wu  2   4 , Szu-Chia Chen  2   5   6   7
Affiliations

Gender Differences in the Relationships among Metabolic Syndrome and Various Obesity-Related Indices with Nonalcoholic Fatty Liver Disease in a Taiwanese Population

I-Ting Lin et al. Int J Environ Res Public Health. .

Abstract

The incidence of nonalcoholic fatty liver disease(NAFLD) is increasing worldwide, and it is strongly associated with metabolic syndrome (MetS) and some obesity-related indices. However, few studies have investigated gender differences in these associations. The aim of this study was to investigate associations among MetS and various obesity-related indices with NAFLD, and also look at gender differences in these associations. We enrolled participants who completed a health survey in southern Taiwan. MetS was defined according to the Adult Treatment Panel III for Asians, and the following obesity-related indices were calculated: body mass index (BMI), waist-to-height ratio (WHtR), waist-hip ratio (WHR), lipid accumulation product (LAP), body roundness index (BRI), conicity index (CI), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), triglyceride-glucose (TyG) index, and hepatic steatosis index (HSI). NAFLD was diagnosed when hepatic steatosis was noted on a liver ultrasound. A total of 1969 (764 men and 1205 women) participants were enrolled. Multivariable analysis showed that both male and female participants with MetS, high BMI, high WHtR, high WHR, high LAP, high BRI, high CI, high VAI, high BAI, high AVI, high TyG index, and high HSI were significantly associated with NAFLD. In addition, the interactions between MetS and gender, WHR and gender, LAP and gender, and TyG index and gender on NAFLD were statistically significant. Among these obesity-related indices, HSI and LAP had the greatest area under the curve in both men and women. Furthermore, stepwise increases in the number of MetS components and the values of indices corresponding to the severity of NAFLD were noted. In conclusion, our results demonstrated significant relationships between MetS and obesity-related indices with NAFLD, and also stepwise increases in the number of MetS components and the values of indices with the severity of NAFLD. MetS, WHR, LAP, and TyG index were associated with NAFLD more obviously in women than in men.

Keywords: gender difference; metabolic syndrome; non-alcoholic fatty liver disease; obesity related indices.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of the predictive value of 11 obesity-related parameters for diagnosis of NAFLD among (A) males and (B) females.
Figure 2
Figure 2
There were significant trends for stepwise increases in the sum of components of MetS corresponding to the severity of NAFLD in study participants.
See this image and copyright information in PMC

References

    1. Bellentani S. The epidemiology of non-alcoholic fatty liver disease. Liver Int. 2017;37:81–84. doi: 10.1111/liv.13299. - DOI - PubMed
    1. Mantovani A., Petracca G., Beatrice G., Tilg H., Byrne C.D., Targher G. Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: An updated meta-analysis of 501 022 adult individuals. Gut. 2020 doi: 10.1136/gutjnl-2020-322572. - DOI - PubMed
    1. Targher G., Byrne C.D., Lonardo A., Zoppini G., Barbui C. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis. J. Hepatol. 2016;65:589–600. doi: 10.1016/j.jhep.2016.05.013. - DOI - PubMed
    1. Saklayen M.G. The Global Epidemic of the Metabolic Syndrome. Curr. Hypertens. Rep. 2018;20:1–8. doi: 10.1007/s11906-018-0812-z. - DOI - PMC - PubMed
    1. Hwang L.-C., Bai C.-H., Chen C.-J. Prevalence of Obesity and Metabolic Syndrome in Taiwan. J. Formos. Med. Assoc. 2006;105:626–635. doi: 10.1016/S0929-6646(09)60161-3. - DOI - PubMed

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