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. 2021 Jan 22;10(3):417.
doi: 10.3390/jcm10030417.

Atherogenic Index of Plasma in Obstructive Sleep Apnoea

Andras Bikov  1   2   3 , Martina Meszaros  1 , Laszlo Kunos  1 , Alina Gabriela Negru  4   5 , Stefan Marian Frent  6   7 , Stefan Mihaicuta  6   7
Affiliations

Atherogenic Index of Plasma in Obstructive Sleep Apnoea

Andras Bikov et al. J Clin Med. .

Abstract

Background: Dyslipidaemia is well recognised in obstructive sleep apnoea (OSA) and could contribute to the development of cardiovascular disease (CVD). Atherogenic index of plasma (AIP) predicts cardiovascular morbidity and mortality better than the individual lipid levels. The aim of this study was to investigate the AIP in patients with OSA in relation with disease severity.

Methods: Four hundred sixty-one patients with OSA and 99 controls participated in this study. AIP was assessed in the morning following a diagnostic sleep study. The association between lipid values and OSA were adjusted for age, gender, and body mass index.

Results: Patients with OSA had higher AIP and triglyceride, and lower high-density lipoprotein cholesterol (HDL-C) levels (all p < 0.05). AIP significantly correlated with the Epworth Sleepiness Scale score (ρ = 0.19), the apnoea-hypopnoea index (ρ = 0.40) and oxygen desaturation index (ρ = 0.43, all p < 0.05). However, there was no relationship between the AIP and markers of sleep quality such as total sleep time, sleep period time, sleep efficiency, arousal index or percentage of REM sleep (all p > 0.05). AIP was not a better predictor for self-reported cardiovascular disease or diabetes than HDL-C.

Conclusions: AIP is elevated in OSA and is related to disease severity. However, it does not seem to have an additional clinical value compared to HDL-C.

Keywords: atherogenic index of plasma; cardiovascular disease; dyslipidemia; sleep apnea.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The relationship between lipid fractions and increasing OSA severity: A. Triglyceride; B. HDL-C; C. Atherogenic index of plasma.
Figure 2
Figure 2
Receiver operating characteristic curve for specific lipid fractions to detect OSA.
See this image and copyright information in PMC

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