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Review
. 2021 May 5:252:119470.
doi: 10.1016/j.saa.2021.119470. Epub 2021 Jan 23.

Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics

Hugh J Byrne  1 , Isha Behl  2 , Genecy Calado  2 , Ola Ibrahim  3 , Mary Toner  4 , Sheila Galvin  5 , Claire M Healy  5 , Stephen Flint  5 , Fiona M Lyng  2
Affiliations
Review

Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics

Hugh J Byrne et al. Spectrochim Acta A Mol Biomol Spectrosc. .

Abstract

Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.

Keywords: Infrared spectroscopy; Oral cancer; Oral pre-cancer; Potentially malignant lesions disease diagnostics; Premalignant lesions; Raman spectroscopy; Vibrational spectroscopy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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