Pumpless Extracorporeal Hemadsorption Technique: A New Method for Early Cytokine Elimination?

Abstract

In recent years, extracorporeal hemadsorption (HA) techniques capable of adsorbing pro- and anti-inflammatory cytokines are increasingly used in various clinical situations. The therapeutic benefit of cytokine elimination likely depends on timing. Although treatment seems to be most effective when started within the first 24 h, therapy is often delayed as it must be combined with another extracorporeal circuit. Thus, using a pumpless extracorporeal HA technique might be a valuable option in order to expedite the commencement of cytokine elimination in critically ill patients.

Keywords: Adsorption; Animal model; Arteriovenous extracorporeal hemadsorption technique; Blood purification; Cytokines; Endotoxin pumpless extracorporeal hemadsorption technique; Extracorporeal hemadsorption; Immunosorbents; Septic shock.