Practice Guideline
doi: 10.1016/j.dld.2020.11.018.
Epub 2021 Jan 25.
Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement
Emanuele Damiano Luca Urso
1
, Maurizio Ponz de Leon
2
, Marco Vitellaro
3
, Guglielmo Niccolò Piozzi
4
, Quoc Riccardo Bao
1
, Aline Martayan
5
, Andrea Remo
6
, Vittoria Stigliano
7
, Cristina Oliani
8
, Emanuela Lucci Cordisco
9
, Salvatore Pucciarelli
1
, Guglielmina Nadia Ranzani
10
, Alessandra Viel
11
; AIFEG group
Collaborators,
Affiliations
Collaborators
-
AIFEG group:
Francesca Adami 12 , Elisa Alducci 13 , Lucia Amadori 14 , Valentina Arcangeli 15 , Luisa Balestrino 16 , Quoc Riccardo Bao 17 , Daniela Barana 18 , Lucio Bertario 19 , Bernardo Bonanni 20 , Stefania Boni 21 , Pierluigi Bullian 22 , Fiorella Carbonardi 23 , Ileana Carnevali 24 , Paola Castelli 25 , Francesco Celotto 26 , Giulia Cini 27 , Gino Crivellari 28 , Duilio Della Libera 29 , Anastasia Dell'elice 30 , Maria Digennaro 31 , Alessandra D'urso 32 , Antonella Fabretto 33 , Daniele Fanale 34 , Irene Feroce 35 , Daniela Furlan 36 , Paola Ghiorzo 37 , Mara Giacché 38 , Milena Gusella 39 , Barbara Liserre 40 , Emanuela Lucci Cordisco 41 , Isabella Mammi 42 , Aline Martayan 43 , Stefania Massuras 44 , Daniela Mazzà 45 , Eleonora Mollica 46 , Alberto Morabito 47 , Giorgia Nardo 48 , Cristina Oliani 49 , Flavia Palermo 50 , Elena Panizza 51 , Margherita Patruno 52 , Monica Pedroni 53 , Valeria Grazia Maria Pensotti 54 , Guglielmo Niccolo Piozzi 4 , Maurizio Ponz de Leon 55 , Simonetta Pozzi 56 , Silvia Presi 57 , Salvatore Pucciarelli 58 , Marta Puzzono 59 , Guglielmina Nadia Ranzani 60 , Mila Ravegnani 61 , Andrea Remo 62 , Maria Teresa Ricci 63 , Luca Roncucci 64 , Giovanni Battsita Rossi 65 , Elena Maria Sala 66 , Lupe Sanchez Mete 67 , Daniele Sandonà 68 , Stefania Sciallero 69 , Davide Serrano 70 , Stefano Signoroni 71 , Francesca Spina 72 , Vittoria Stigliano 73 , Monica Taborelli 74 , Gianluca Tedaldi 75 , Maria Grazia Tibiletti 76 , Silvia Tognazzo 77 , Gianluca Tolva 78 , Cristina Maria Concetta Trovato 79 , Daniela Turchetti 80 , Emanuele Damiano Luca Urso 81 , Dora Varvara 82 , Alessandra Viel 83 , Marco Vitellaro 84 , Caterina Vivanet 85 , Stefania Zovato 86 , Raffaella Alessia Zuppardo 87
Affiliations
- 1 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padua, Italy.
- 2 Department of Internal Medicine, University of Modena and Reggio Emilia. Retired, Italy.
- 3 Unit of Hereditary Digestive Tract Tumors, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Colorectal Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: marco.vitellaro@istitutotumori.mi.it.
- 4 Colorectal Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
- 5 Clinical Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
- 6 Pathology Unit, Services Department, ULSS9 Scaligera, Verona, Italy.
- 7 Division of Gastroenterology and Digestive Endoscopy, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
- 8 Medical Oncology Unit, ULSS 5 Polesana, Rovigo, Italy.
- 9 Institute of Genomic Medicine, Catholic University, Rome, Italy.
- 10 Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
- 11 Functional Oncogenomics and Genetics Unit, IRCCS Centro di Riferimento Oncologico di Aviano (CRO), Aviano, Italy.
- 12 Medical Oncology, Azienda Ospedaliera "Carlo Poma", Strada Lago Paiolo 10, Mantua 46100, Italy.
- 13 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address: elisa.alducci@iov.veneto.it.
- 14 Department of Internal Medicine, Modena University Hospital, Modena, Italy.
- 15 Department of Medical Oncology, Ospedale Infermi, Rimini 47923, Italy. Electronic address: valentina.arcangeli@auslromagna.it.
- 16 Genetica Medica, Dipartimento di Scienze Mediche e Sanità Pubblica, Università di Cagliari, Caligria, Italy.
- 17 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, , Italy. Electronic address: bqr@hotmail.it.
- 18 Oncology Unit, Local Health and Social Care Unit ULSS8 Berica, Montecchio Maggiore, Italy.
- 19 Scientific Consultant of the Division of Prevention and Genetic Oncology, European Institute of Oncology, Milan 20141, Italy.
- 20 Division of Prevention and Genetic Oncology, European Institute of Oncology, Milan 20141, Italy. Electronic address: bernardo.bonanni@ieo.it.
- 21 Medical Genetics Unit, San Martino Hospital, Belluno, Italy. Electronic address: stefania.boni@alice.it.
- 22 Medical Oncology, Ulss 1, Feltre Hospital, Feltre, Italy.
- 23 Medical Oncology, Azienda Ospedaliera "Carlo Poma", Strada Lago Paiolo 10, Mantua 46100, Italy. Electronic address: fiorella.carbonardi@asst-mantova.it.
- 24 Research Center for the Study of Hereditary and Familial Tumors, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: ileana.carnevali@asst-settelaghi.it.
- 25 Department of Pathology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy. Electronic address: paola.castelli@sacrocuore.it.
- 26 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Giustiniani 2, Padova 35128, Italy.
- 27 Functional Oncogenomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN, Italy. Electronic address: cinigiulia@cro.it.
- 28 Clinical and Experimental Oncology Department, Veneto Institute of Oncology IOV - IRCCS, Padua - Italy. Electronic address: gino.crivellari@iov.veneto.it.
- 29 Oncological Gastrointestinal Surgery Department, S. Maria del Prato Hospital, Feltre, Italy.
- 30 Department of Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN, Italy.
- 31 Experimental Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, Bari I-70124, Italy. Electronic address: madi1963@libero.it.
- 32 U.O.C. Anatomia Patologica, ULSS1 Dolomiti, Presidio Ospedaliero di Feltre, Feltre 32032, Italy. Electronic address: alessandra.durso@aulss1.veneto.it.
- 33 S.C. Genetica Medica, IRCCS Burlo Garofolo, Trieste, Italy. Electronic address: antonella.fabretto@burlo.trieste.it.
- 34 Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo 90127, Italy. Electronic address: fandan@libero.it.
- 35 Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti, 435, Milan 20141, Italy. Electronic address: irene.feroce@ieo.it.
- 36 Anatomic Pathology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: daniela.furlan@uninsubria.it.
- 37 Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: paola.ghiorzo@unige.it.
- 38 Endocrine and Metabolic Disease Unit, Department of Medicine, ASST Spedali Civili of Brescia, Brescia, Italy. Electronic address: mara.giacche@ASST-spedalicivili.it.
- 39 Oncology Unit, AULSS5 Polesana, Rovigo, Italy. Electronic address: milenagusella@libero.it.
- 40 Department of Pathology, Fondazione Poliambulanza, Brescia, Italy. Electronic address: barbara.liserre@poliambulanza.it.
- 41 Institute of Genomic Medicine, Catholic University, Rome, Italy. Electronic address: emanuela.luccicordisco@unicatt.it.
- 42 Medical Genetics Unit, Dolo General Hospital, Venezia, Italy. Electronic address: isabella.mammi@iov.veneto.it.
- 43 Clinical Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: aline_martayan@yahoo.it.
- 44 Department of Medical Genetics, University of Torino, Torino, Italy. Electronic address: stefania.massuras@unito.it.
- 45 Fondazione Policlinico Universitario A. Gemelli IRCCS, Unità Operativa Complessa di Genetica Medica, Rome, Italy.
- 46 S.C. Chirurgia Generale, Portogruaro, VE, Italy.
- 47 Oncology, Cittadella, PD, Italy.
- 48 U.O.C. Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV IRCCS, Padova 35128, Italy. Electronic address: giorgia.nardo@iov.veneto.it.
- 49 Medical Oncology, Ulss 5 Polesana, Rovigo, Italy. Electronic address: cristina.oliani@aulss5.veneto.it.
- 50 Department of Genetics, University of Genova, Genova, Italy.
- 51 Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address: elena.panizza@asst-mantova.it.
- 52 Experimental Oncology-Center for the Study of Hereditary Cancers, IRCCS-Istituto Tumori "Giovanni Paolo II", Bari, Italy.
- 53 Dipartimento di Medicina Diagnostica, Clinica e Sanità Pubblica, Università di Modena e Reggio Emilia, Policlinico, Via del Pozzo n.71, Modena 41100, Italy. Electronic address: monica.pedroni@unimore.it.
- 54 Cogentech s.r.l. Società Benefit a Socio Unico, Milan, Italy. Electronic address: valeria.pensotti@cogentech.it.
- 55 Dipartimento di Medicina Interna, Università di Modena e Reggio Emilia. Retired, Italy.
- 56 Division of Abdomino-Pelvic and Minimally Invasive Surgery, European Institute of Oncology, Via G. Ripamonti, 435, Milan 20141, Italy. Electronic address: simonetta.pozzi@ieo.it.
- 57 Clinical Molecular Biology Laboratory, IRCCS San Raffaele Hospital, Milan, Italy. Electronic address: presi.silvia@hsr.it.
- 58 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Italy. Electronic address: puc@unipd.it.
- 59 Division of Experimental Oncology, Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS Ospedale San Raffaele Scientific Institute, Milan 20132, Italy. Electronic address: tp33@hotmail.it.
- 60 Department of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy. Electronic address: guglielmina.ranzani@unipv.it.
- 61 Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola 47014, Italy. Electronic address: mila.ravegnani@irst.emr.it.
- 62 Pathology Unit, Services Department, ULSS9 "Scaligera", Verona 37122, Italy. Electronic address: andrea.remo@aulss9.veneto.it.
- 63 Unit of Hereditary Digestive Tract Tumour Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: mariateresa.ricci@istitutotumori.mi.it.
- 64 Department of Diagnostic and Clinical Medicine, and Public Health, University of Modena and Reggio Emilia, Modena I-41125, Italy. Electronic address: luca.roncucci@unimore.it.
- 65 Endoscopy Unit, National Cancer Institute and Pascale Foundation, Naples, Italy. Electronic address: g.rossi@istitutotumori.na.it.
- 66 Medical Genetics Laboratory, Clinical Pathology Department, S. Gerardo Hospital, Monza 20900, Italy. Electronic address: elena.sala@asst-monza.it.
- 67 Division of Gastroenterology and Digestive Endoscopy, Regina Elena National Cancer Institute, Rome, Italy. Electronic address: lupe.sanchez@ifo.gov.it.
- 68 Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, PD, Italy. Electronic address: daniele.sandona.2@studenti.unipd.it.
- 69 Ospedale Policlinico San Martino IRCCS, Genoa, Italy. Electronic address: stefania.sciallero@hsanmartino.it.
- 70 Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti, 435, Milan 20141, Italy. Electronic address: davide.serrano@ieo.it.
- 71 Unit of Hereditary Digestive Tract Tumour Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: stefanosignoroni@yahoo.it.
- 72 Department of Medical Genetics, Binaghi Hospital, Cagliari, Italy.
- 73 Division of Gastroenterology and Digestive Endoscopy IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: vittoria.stigliano@ifo.gov.it.
- 74 Cytogenetics laboratory, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. Electronic address: monica.taborelli@eoc.ch.
- 75 Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. Electronic address: gianluca.tedaldi@irst.emr.it.
- 76 Ospedale di Circolo ASST Settelaghi, Centro di Ricerca Tumori Eredo-Familiari, Università dell'Insubria, Varese 21100, Italy. Electronic address: MariaGrazia.Tibiletti@asst-settelaghi.it.
- 77 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address: silvia.tognazzo@iov.veneto.it.
- 78 Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address: jankska@yahoo.it.
- 79 Division of Endoscopy, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address: cristina.trovato@ieo.it.
- 80 Center for Hereditary Cancer Studies, Department of Medical and Surgical Sciences, S. Orsola-Malpighi University Hospital, Bologna, Italy. Electronic address: daniela.turchetti@unibo.it.
- 81 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Italy. Electronic address: edl.urso@unipd.it.
- 82 Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari, Bari, Italy. Electronic address: dora.varvara@yahoo.it.
- 83 Functional Onco-Genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. Electronic address: aviel@cro.it.
- 84 Unit of Hereditary Digestive Tract Tumour Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: Marco.Vitellaro@istitutotumori.mi.it.
- 85 Department of Medical Genetics, Cagliari Hospital, Cagliari, Italy. Electronic address: cateviva@libero.it.
- 86 Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology IOV- IRCCS, Padua, Italy. Electronic address: stefania.zovato@iov.veneto.it.
- 87 Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy. Electronic address: zuppardo.raffaellaalessia@hsr.it.
- PMID: 33504457
- DOI: 10.1016/j.dld.2020.11.018
Item in Clipboard
Practice Guideline
Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement
Emanuele Damiano Luca Urso et al.
Dig Liver Dis.
2021 Apr.
Display options
Format
doi: 10.1016/j.dld.2020.11.018.
Epub 2021 Jan 25.
Authors
Emanuele Damiano Luca Urso
1
, Maurizio Ponz de Leon
2
, Marco Vitellaro
3
, Guglielmo Niccolò Piozzi
4
, Quoc Riccardo Bao
1
, Aline Martayan
5
, Andrea Remo
6
, Vittoria Stigliano
7
, Cristina Oliani
8
, Emanuela Lucci Cordisco
9
, Salvatore Pucciarelli
1
, Guglielmina Nadia Ranzani
10
, Alessandra Viel
11
; AIFEG group
Collaborators
-
AIFEG group:
Francesca Adami 12 , Elisa Alducci 13 , Lucia Amadori 14 , Valentina Arcangeli 15 , Luisa Balestrino 16 , Quoc Riccardo Bao 17 , Daniela Barana 18 , Lucio Bertario 19 , Bernardo Bonanni 20 , Stefania Boni 21 , Pierluigi Bullian 22 , Fiorella Carbonardi 23 , Ileana Carnevali 24 , Paola Castelli 25 , Francesco Celotto 26 , Giulia Cini 27 , Gino Crivellari 28 , Duilio Della Libera 29 , Anastasia Dell'elice 30 , Maria Digennaro 31 , Alessandra D'urso 32 , Antonella Fabretto 33 , Daniele Fanale 34 , Irene Feroce 35 , Daniela Furlan 36 , Paola Ghiorzo 37 , Mara Giacché 38 , Milena Gusella 39 , Barbara Liserre 40 , Emanuela Lucci Cordisco 41 , Isabella Mammi 42 , Aline Martayan 43 , Stefania Massuras 44 , Daniela Mazzà 45 , Eleonora Mollica 46 , Alberto Morabito 47 , Giorgia Nardo 48 , Cristina Oliani 49 , Flavia Palermo 50 , Elena Panizza 51 , Margherita Patruno 52 , Monica Pedroni 53 , Valeria Grazia Maria Pensotti 54 , Guglielmo Niccolo Piozzi 4 , Maurizio Ponz de Leon 55 , Simonetta Pozzi 56 , Silvia Presi 57 , Salvatore Pucciarelli 58 , Marta Puzzono 59 , Guglielmina Nadia Ranzani 60 , Mila Ravegnani 61 , Andrea Remo 62 , Maria Teresa Ricci 63 , Luca Roncucci 64 , Giovanni Battsita Rossi 65 , Elena Maria Sala 66 , Lupe Sanchez Mete 67 , Daniele Sandonà 68 , Stefania Sciallero 69 , Davide Serrano 70 , Stefano Signoroni 71 , Francesca Spina 72 , Vittoria Stigliano 73 , Monica Taborelli 74 , Gianluca Tedaldi 75 , Maria Grazia Tibiletti 76 , Silvia Tognazzo 77 , Gianluca Tolva 78 , Cristina Maria Concetta Trovato 79 , Daniela Turchetti 80 , Emanuele Damiano Luca Urso 81 , Dora Varvara 82 , Alessandra Viel 83 , Marco Vitellaro 84 , Caterina Vivanet 85 , Stefania Zovato 86 , Raffaella Alessia Zuppardo 87
Affiliations
- 1 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padua, Italy.
- 2 Department of Internal Medicine, University of Modena and Reggio Emilia. Retired, Italy.
- 3 Unit of Hereditary Digestive Tract Tumors, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Colorectal Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: marco.vitellaro@istitutotumori.mi.it.
- 4 Colorectal Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
- 5 Clinical Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
- 6 Pathology Unit, Services Department, ULSS9 Scaligera, Verona, Italy.
- 7 Division of Gastroenterology and Digestive Endoscopy, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
- 8 Medical Oncology Unit, ULSS 5 Polesana, Rovigo, Italy.
- 9 Institute of Genomic Medicine, Catholic University, Rome, Italy.
- 10 Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
- 11 Functional Oncogenomics and Genetics Unit, IRCCS Centro di Riferimento Oncologico di Aviano (CRO), Aviano, Italy.
- 12 Medical Oncology, Azienda Ospedaliera "Carlo Poma", Strada Lago Paiolo 10, Mantua 46100, Italy.
- 13 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address: elisa.alducci@iov.veneto.it.
- 14 Department of Internal Medicine, Modena University Hospital, Modena, Italy.
- 15 Department of Medical Oncology, Ospedale Infermi, Rimini 47923, Italy. Electronic address: valentina.arcangeli@auslromagna.it.
- 16 Genetica Medica, Dipartimento di Scienze Mediche e Sanità Pubblica, Università di Cagliari, Caligria, Italy.
- 17 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, , Italy. Electronic address: bqr@hotmail.it.
- 18 Oncology Unit, Local Health and Social Care Unit ULSS8 Berica, Montecchio Maggiore, Italy.
- 19 Scientific Consultant of the Division of Prevention and Genetic Oncology, European Institute of Oncology, Milan 20141, Italy.
- 20 Division of Prevention and Genetic Oncology, European Institute of Oncology, Milan 20141, Italy. Electronic address: bernardo.bonanni@ieo.it.
- 21 Medical Genetics Unit, San Martino Hospital, Belluno, Italy. Electronic address: stefania.boni@alice.it.
- 22 Medical Oncology, Ulss 1, Feltre Hospital, Feltre, Italy.
- 23 Medical Oncology, Azienda Ospedaliera "Carlo Poma", Strada Lago Paiolo 10, Mantua 46100, Italy. Electronic address: fiorella.carbonardi@asst-mantova.it.
- 24 Research Center for the Study of Hereditary and Familial Tumors, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: ileana.carnevali@asst-settelaghi.it.
- 25 Department of Pathology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy. Electronic address: paola.castelli@sacrocuore.it.
- 26 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Via Giustiniani 2, Padova 35128, Italy.
- 27 Functional Oncogenomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN, Italy. Electronic address: cinigiulia@cro.it.
- 28 Clinical and Experimental Oncology Department, Veneto Institute of Oncology IOV - IRCCS, Padua - Italy. Electronic address: gino.crivellari@iov.veneto.it.
- 29 Oncological Gastrointestinal Surgery Department, S. Maria del Prato Hospital, Feltre, Italy.
- 30 Department of Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN, Italy.
- 31 Experimental Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, Bari I-70124, Italy. Electronic address: madi1963@libero.it.
- 32 U.O.C. Anatomia Patologica, ULSS1 Dolomiti, Presidio Ospedaliero di Feltre, Feltre 32032, Italy. Electronic address: alessandra.durso@aulss1.veneto.it.
- 33 S.C. Genetica Medica, IRCCS Burlo Garofolo, Trieste, Italy. Electronic address: antonella.fabretto@burlo.trieste.it.
- 34 Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo 90127, Italy. Electronic address: fandan@libero.it.
- 35 Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti, 435, Milan 20141, Italy. Electronic address: irene.feroce@ieo.it.
- 36 Anatomic Pathology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: daniela.furlan@uninsubria.it.
- 37 Genetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: paola.ghiorzo@unige.it.
- 38 Endocrine and Metabolic Disease Unit, Department of Medicine, ASST Spedali Civili of Brescia, Brescia, Italy. Electronic address: mara.giacche@ASST-spedalicivili.it.
- 39 Oncology Unit, AULSS5 Polesana, Rovigo, Italy. Electronic address: milenagusella@libero.it.
- 40 Department of Pathology, Fondazione Poliambulanza, Brescia, Italy. Electronic address: barbara.liserre@poliambulanza.it.
- 41 Institute of Genomic Medicine, Catholic University, Rome, Italy. Electronic address: emanuela.luccicordisco@unicatt.it.
- 42 Medical Genetics Unit, Dolo General Hospital, Venezia, Italy. Electronic address: isabella.mammi@iov.veneto.it.
- 43 Clinical Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: aline_martayan@yahoo.it.
- 44 Department of Medical Genetics, University of Torino, Torino, Italy. Electronic address: stefania.massuras@unito.it.
- 45 Fondazione Policlinico Universitario A. Gemelli IRCCS, Unità Operativa Complessa di Genetica Medica, Rome, Italy.
- 46 S.C. Chirurgia Generale, Portogruaro, VE, Italy.
- 47 Oncology, Cittadella, PD, Italy.
- 48 U.O.C. Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV IRCCS, Padova 35128, Italy. Electronic address: giorgia.nardo@iov.veneto.it.
- 49 Medical Oncology, Ulss 5 Polesana, Rovigo, Italy. Electronic address: cristina.oliani@aulss5.veneto.it.
- 50 Department of Genetics, University of Genova, Genova, Italy.
- 51 Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address: elena.panizza@asst-mantova.it.
- 52 Experimental Oncology-Center for the Study of Hereditary Cancers, IRCCS-Istituto Tumori "Giovanni Paolo II", Bari, Italy.
- 53 Dipartimento di Medicina Diagnostica, Clinica e Sanità Pubblica, Università di Modena e Reggio Emilia, Policlinico, Via del Pozzo n.71, Modena 41100, Italy. Electronic address: monica.pedroni@unimore.it.
- 54 Cogentech s.r.l. Società Benefit a Socio Unico, Milan, Italy. Electronic address: valeria.pensotti@cogentech.it.
- 55 Dipartimento di Medicina Interna, Università di Modena e Reggio Emilia. Retired, Italy.
- 56 Division of Abdomino-Pelvic and Minimally Invasive Surgery, European Institute of Oncology, Via G. Ripamonti, 435, Milan 20141, Italy. Electronic address: simonetta.pozzi@ieo.it.
- 57 Clinical Molecular Biology Laboratory, IRCCS San Raffaele Hospital, Milan, Italy. Electronic address: presi.silvia@hsr.it.
- 58 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Italy. Electronic address: puc@unipd.it.
- 59 Division of Experimental Oncology, Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS Ospedale San Raffaele Scientific Institute, Milan 20132, Italy. Electronic address: tp33@hotmail.it.
- 60 Department of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy. Electronic address: guglielmina.ranzani@unipv.it.
- 61 Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola 47014, Italy. Electronic address: mila.ravegnani@irst.emr.it.
- 62 Pathology Unit, Services Department, ULSS9 "Scaligera", Verona 37122, Italy. Electronic address: andrea.remo@aulss9.veneto.it.
- 63 Unit of Hereditary Digestive Tract Tumour Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: mariateresa.ricci@istitutotumori.mi.it.
- 64 Department of Diagnostic and Clinical Medicine, and Public Health, University of Modena and Reggio Emilia, Modena I-41125, Italy. Electronic address: luca.roncucci@unimore.it.
- 65 Endoscopy Unit, National Cancer Institute and Pascale Foundation, Naples, Italy. Electronic address: g.rossi@istitutotumori.na.it.
- 66 Medical Genetics Laboratory, Clinical Pathology Department, S. Gerardo Hospital, Monza 20900, Italy. Electronic address: elena.sala@asst-monza.it.
- 67 Division of Gastroenterology and Digestive Endoscopy, Regina Elena National Cancer Institute, Rome, Italy. Electronic address: lupe.sanchez@ifo.gov.it.
- 68 Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, PD, Italy. Electronic address: daniele.sandona.2@studenti.unipd.it.
- 69 Ospedale Policlinico San Martino IRCCS, Genoa, Italy. Electronic address: stefania.sciallero@hsanmartino.it.
- 70 Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Via Giuseppe Ripamonti, 435, Milan 20141, Italy. Electronic address: davide.serrano@ieo.it.
- 71 Unit of Hereditary Digestive Tract Tumour Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: stefanosignoroni@yahoo.it.
- 72 Department of Medical Genetics, Binaghi Hospital, Cagliari, Italy.
- 73 Division of Gastroenterology and Digestive Endoscopy IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: vittoria.stigliano@ifo.gov.it.
- 74 Cytogenetics laboratory, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. Electronic address: monica.taborelli@eoc.ch.
- 75 Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. Electronic address: gianluca.tedaldi@irst.emr.it.
- 76 Ospedale di Circolo ASST Settelaghi, Centro di Ricerca Tumori Eredo-Familiari, Università dell'Insubria, Varese 21100, Italy. Electronic address: MariaGrazia.Tibiletti@asst-settelaghi.it.
- 77 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address: silvia.tognazzo@iov.veneto.it.
- 78 Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address: jankska@yahoo.it.
- 79 Division of Endoscopy, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address: cristina.trovato@ieo.it.
- 80 Center for Hereditary Cancer Studies, Department of Medical and Surgical Sciences, S. Orsola-Malpighi University Hospital, Bologna, Italy. Electronic address: daniela.turchetti@unibo.it.
- 81 Clinica Chirurgica I, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University Hospital of Padova, Italy. Electronic address: edl.urso@unipd.it.
- 82 Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari, Bari, Italy. Electronic address: dora.varvara@yahoo.it.
- 83 Functional Onco-Genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. Electronic address: aviel@cro.it.
- 84 Unit of Hereditary Digestive Tract Tumour Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: Marco.Vitellaro@istitutotumori.mi.it.
- 85 Department of Medical Genetics, Cagliari Hospital, Cagliari, Italy. Electronic address: cateviva@libero.it.
- 86 Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology IOV- IRCCS, Padua, Italy. Electronic address: stefania.zovato@iov.veneto.it.
- 87 Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy. Electronic address: zuppardo.raffaellaalessia@hsr.it.
- PMID: 33504457
- DOI: 10.1016/j.dld.2020.11.018
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Abstract
An expert consensus panel convened by the Italian Association for Inherited and Familial Gastrointestinal Tumors (Associazione Italiana per lo Studio della Familiarità ed Ereditarietà dei Tumori Gastrointestinali, AIFEG) reviewed the literature and agreed on a number of position statements regarding the definition and management of polyposis coli without an identified pathogenic mutation on the APC or MUTYH genes, defined in the document as NAMP (non-APC/MUTYH polyposis).
Keywords: Cancer Genetics; Colorectal cancer; Colorectal polyposis not associated with APC/MUTYH mutation; Consensus development conference; Endoscopic surveillance; Polyposis management guideline; Surgical Management.
Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest None declared
Comment in
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Commentary on "Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement".Dhooge M, Saurin JC. Dhooge M, et al. Dig Liver Dis. 2021 Apr;53(4):418-419. doi: 10.1016/j.dld.2021.02.002. Epub 2021 Mar 3. Dig Liver Dis. 2021. PMID: 33674216 No abstract available.
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