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Review
. 2021 Jan 5:2021:6634532.
doi: 10.1155/2021/6634532. eCollection 2021.

The Effect of Lipid Metabolism on CD4+ T Cells

Feiyang Cai  1 , Shuxin Jin  1 , Guangjie Chen  1
Affiliations
Review

The Effect of Lipid Metabolism on CD4+ T Cells

Feiyang Cai et al. Mediators Inflamm. .

Abstract

CD4+ T cells play a vital role in the adaptive immune system and are involved in the pathogenesis of many diseases, including cancer, autoimmune diseases, and chronic inflammation. As an important mechanism for energy storage, a lot of researches have clarified that metabolism imbalance interacts with immune disorder, and one leads to the other. Lipid metabolism has close relationship with CD4+ T cells. In this review, we discuss fatty acid, cholesterol, prostaglandin, and phospholipid metabolism in CD4+ T cell subsets. Fatty acid β-oxidation (FAO) is activated in Th17 cell to support the proinflammatory function. Cholesterol promotes Th1, Th2, and Treg cell differentiation. In addition to glucose metabolism, lipid metabolism is also very important for immunity. Here, it is highlighted that lipid metabolism regulates CD4+ T cell differentiation and function and is related to diseases.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The role of lipid metabolism in CD4+ T cell differentiation.Multiple signals affect lipid biosynthesis and degradation. Moreover, lipids, such as fatty acid and cholesterol, also activate multiple signals to regulate T cell differentiation. →: stimulation; ⊣: inhibition.
See this image and copyright information in PMC

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