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Review
. 2021 Jan 5:2021:8834590.
doi: 10.1155/2021/8834590. eCollection 2021.

An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases

Yanyun Li  1 , Ziyu Ye  1   2 , Weiqin Yang  1 , Qunzhou Zhang  2 , Jincheng Zeng  1
Affiliations
Review

An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases

Yanyun Li et al. Stem Cells Int. .

Abstract

Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. Therefore, understanding the biological and immunological characteristics of MSCs is important to standardize and optimize MSC-based regenerative therapy. In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic representation of the mechanisms of MSCs to promote tissue repair and immunosuppression. (a) Self-renewal and multipotent differentiation functions. (b) Low immunogenicity. (c) Transfer of biologically active substances by paracrine or EVs. (d) Immunomodulatory properties.
See this image and copyright information in PMC

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