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Review
. 2020 Dec 26;12(12):1511-1528.
doi: 10.4252/wjsc.v12.i12.1511.

Prospects for the therapeutic development of umbilical cord blood-derived mesenchymal stem cells

Soyoun Um  1 , Jueun Ha  2 , Soo Jin Choi  3 , Wonil Oh  3 , Hye Jin Jin  4
Affiliations
Review

Prospects for the therapeutic development of umbilical cord blood-derived mesenchymal stem cells

Soyoun Um et al. World J Stem Cells. .

Abstract

Umbilical cord blood (UCB) is a primitive and abundant source of mesenchymal stem cells (MSCs). UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders. Despite the high latent self-renewal and differentiation capacity of these cells, the safety, efficacy, and yield of MSCs expanded for ex vivo clinical applications remains a concern. However, immunomodulatory effects have emerged in various disease models, exhibiting specific mechanisms of action, such as cell migration and homing, angiogenesis, anti-apoptosis, proliferation, anti-cancer, anti-fibrosis, anti-inflammation and tissue regeneration. Herein, we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies, and discuss the concerns regarding the safety and mass production issues in future applications.

Keywords: Immunomodulation; Mesenchymal stem cell; Regenerative medicine; Stem cell therapy; Therapeutic cell manufacturing processing; Umbilical cord blood.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mechanisms of action mediated by umbilical cord blood-derived mesenchymal stem cells. SDF: Stromal cell-derived factor; VCAM: Vascular cell adhesion molecule; MMP: Matrix metalloproteinase; HGF: Hepatocyte growth factor; PDGF: Platelet-derived growth factor; MCP: Monocyte chemoattractant protein; FGF: Fibroblast growth factor; PTX: Pentraxin-related protein; TGF: Transforming growth factor; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand; GDF: Growth/differentiation factor; ICAM: Intercellular adhesion molecule; BDNF: Brain-derived neurotrophic factor; VEGF: Vascular endothelial growth factor; FGF: Fibroblast growth factor; UCB: Umbilical cord blood; MSC: Mesenchymal stem cell.
Figure 2
Figure 2
Workflow for therapeutic cell manufacturing processing.
See this image and copyright information in PMC

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