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. 2019 Dec 5;33(1):80-86.
doi: 10.4103/tcmj.tcmj_198_19. eCollection 2021 Jan-Mar.

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Sarika Pandey  1 , Rajiv Garg  1 , Surya Kant  1 , Priyanka Gaur  2
Affiliations

Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Sarika Pandey et al. Tzu Chi Med J. .

Abstract

Objective: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects.

Materials and methods: The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data.

Results: The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher (P = 0.0001).

Conclusion: The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease.

Keywords: Antioxidants; C-reactive protein; Chronic obstructive pulmonary disease; Oxidative stress; Vitamin D.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical symptoms in chronic obstructive pulmonary disease patients
Figure 2
Figure 2
Inflammatory and antioxidant/oxidant parameters in chronic obstructive pulmonary disease patients and healthy controls
Figure 3
Figure 3
Inflammatory and antioxidants/oxidative stress parameters in chronic obstructive pulmonary disease patients and healthy controls on the basis of smoking status
Figure 4
Figure 4
Inflammatory and antioxidants/oxidative stress parameters in chronic obstructive pulmonary disease patients on the basis of severity
See this image and copyright information in PMC

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References

    1. Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, et al. Chronic obstructive pulmonary disease: Current burden and future projections. Eur Respir J. 2006;27:397–412. - PubMed
    1. Barnes PJ. COPD: Is there light at the end of the tunnel? Curr Opin Pharmacol. 2004;4:263–72. - PubMed
    1. Saetta M, Turato G, Maestrelli P, Mapp CE, Fabbri LM. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:1304–9. - PubMed
    1. Grashoff WF, Sont JK, Sterk PJ, Hiemstra PS, de Boer WI, Stolk J, et al. Chronic obstructive pulmonary disease: Role of bronchiolar mast cells and macrophages. Am J Pathol. 1997;151:1785–90. - PMC - PubMed
    1. Cristóvão C, Cristóvão L, Nogueira F, Bicho M. Evaluation of the oxidant and antioxidant balance in the pathogenesis of chronic obstructive pulmonary disease. Rev Port Pneumol. 2013;19:70–5. - PubMed