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Review
. 2021 Jan 11:2021:6678142.
doi: 10.1155/2021/6678142. eCollection 2021.

Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications

Ana-Maria Singeap  1   2 , Carol Stanciu  2 , Laura Huiban  1   2 , Cristina Maria Muzica  1   2 , Tudor Cuciureanu  1   2 , Irina Girleanu  1   2 , Stefan Chiriac  1   2 , Sebastian Zenovia  1   2 , Robert Nastasa  1   2 , Catalin Sfarti  1   2 , Camelia Cojocariu  1   2 , Anca Trifan  1   2
Affiliations
Review

Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications

Ana-Maria Singeap et al. Can J Gastroenterol Hepatol. .

Abstract

Nonalcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. Recently, there has been increasing evidence of the association between NAFLD and a number of endocrinopathies, such as hypothyroidism, polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism, and hypercortisolism. Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. In this review, we present the main relationships between NAFLD and endocrinopathies, emphasizing the reciprocal causality, evolutive interconnections, and current clinical scenarios of presentations of which the clinicians should be aware.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

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