Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 8;3(1):vdaa175.
doi: 10.1093/noajnl/vdaa175. eCollection 2021 Jan-Dec.

An updated histology recode for the analysis of primary malignant and nonmalignant brain and other central nervous system tumors in the Surveillance, Epidemiology, and End Results Program

Gonçalo Forjaz  1 , Jill S Barnholtz-Sloan  2   3 , Carol Kruchko  2 , Rebecca Siegel  4 , Serban Negoita  1 , Quinn T Ostrom  2   5 , Lois Dickie  1 , Jennifer Ruhl  1 , Alison Van Dyke  1 , Nirav Patil  2 , Gino Cioffi  2   3 , Kimberly D Miller  4 , Kristin Waite  2   3 , Angela B Mariotto  1
Affiliations

An updated histology recode for the analysis of primary malignant and nonmalignant brain and other central nervous system tumors in the Surveillance, Epidemiology, and End Results Program

Gonçalo Forjaz et al. Neurooncol Adv. .

Abstract

Background: There are over 100 histologically distinct types of primary malignant and nonmalignant brain and other central nervous system (CNS) tumors. Our study presents recent trends in the incidence of these tumors using an updated histology recode that incorporates major diagnostic categories listed in the 2016 World Health Organization Classification of Tumours of the CNS.

Methods: We used data from the SEER-21 registries for patients of all ages diagnosed in 2000-2017. We calculated age-adjusted incidence rates and fitted a joinpoint regression to the observed data to estimate the Annual Percent Change and 95% confidence intervals over the period 2000-2017.

Results: There were 315,184 new malignant (34.2%; 107,890) and nonmalignant (65.8%; 207,294) brain tumor cases during 2004-2017. Nonmalignant meningioma represented 46.5% (146,498) of all brain tumors (malignant and nonmalignant), while glioblastoma represented 50.8% (54,832) of all malignant tumors. Temporal trends were stable or declining except for nonmalignant meningioma (0.7% per year during 2004-2017). Several subtypes presented decreases in trends in the most recent period (2013-2017): diffuse/anaplastic astrocytoma (-1.3% per year, oligodendroglioma (-2.6%), pilocytic astrocytoma (-3.8%), and malignant meningioma (-5.9%).

Conclusions: Declining trends observed in our study may be attributable to recent changes in diagnostic classification and the coding practices stemming from those changes. The recode used in this study enables histology reporting to reflect the changes. It also provides a first step toward the reporting of malignant and nonmalignant brain and other CNS tumors in the Surveillance, Epidemiology, and End Results (SEER) Program by clinically relevant histology groupings.

Keywords: brain tumors; classifications; incidence; trends.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Trends in age-standardized incidence rates for selected malignant (2000–2017) and nonmalignant (2004–2017) brain and other CNS tumors in the SEER 21 registries, by age group—Both sexes. Symbols represent observed data; lines represent modeled data. The rates are plotted on the log scale.
Figure 2.
Figure 2.
Trends in age-standardized incidence rates for selected malignant (2000–2017) and nonmalignant (2004–2017) brain and other CNS tumors in the SEER 21 registries, by race/ethnicity—Men. Symbols represent observed data; lines represent modeled data. The rates are plotted on the log scale. NHW, non-Hispanic white; NHB, non-Hispanic Black.
Figure 3.
Figure 3.
Trends in age-standardized incidence rates for selected malignant (2000–2017) and nonmalignant (2004–2017) brain and other CNS tumors in the SEER 21 registries, by race/ethnicity—Women. Symbols represent observed data; lines represent modeled data. The rates are plotted on the log scale. NHW, non-Hispanic white; NHB, non-Hispanic Black.
See this image and copyright information in PMC

References

    1. Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro Oncol. 2020;22(Supplement_1):iv1–iv96. - PMC - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30. - PubMed
    1. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975–2017, National Cancer Institute; Bethesda, MD, based on November 2019 SEER data submission, posted to the SEER web site, April 2020 https://seer.cancer.gov/csr/1975_2017/.
    1. SEER*Explorer: An interactive website for SEER cancer statistics [Internet]. Surveillance research program National Cancer Institute; https://seer.cancer.gov/explorer/. Accessed March 12, 2020.
    1. Amirian ES, Ostrom QT, Liu Y, Barnholtz-Sloan JS, Bondy ML. Nervous system. In: Thun M, Linet MS, Cerhan JR, Haiman CA, Schottenfeld D, eds. Schottenfeld and Fraumeni Cancer Epidemiology and Prevention. New York: Oxford University Press; 2018: 1039–1060.

LinkOut - more resources